ID F2CCR8_STRSA Unreviewed; 124 AA. AC F2CCR8; DT 31-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-MAY-2011, sequence version 1. DT 13-FEB-2019, entry version 29. DE RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN Name=crcB2 {ECO:0000313|EMBL:EGF19828.1}; GN Synonyms=crcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN ORFNames=HMPREF9391_0548 {ECO:0000313|EMBL:EGF19828.1}; OS Streptococcus sanguinis SK408. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=888818 {ECO:0000313|EMBL:EGF19828.1, ECO:0000313|Proteomes:UP000004826}; RN [1] {ECO:0000313|EMBL:EGF19828.1, ECO:0000313|Proteomes:UP000004826} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SK408 {ECO:0000313|EMBL:EGF19828.1, RC ECO:0000313|Proteomes:UP000004826}; RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., RA Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., RA Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., RA Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., RA San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., RA Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., RA Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., RA Petrosino J., Highlander S., Gibbs R.; RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Important for reducing fluoride concentration in the CC cell, thus reducing its toxicity. {ECO:0000256|HAMAP- CC Rule:MF_00454, ECO:0000256|SAAS:SAAS00096000}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP- CC Rule:MF_00454}; Multi-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_00454}. CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. CC {ECO:0000256|HAMAP-Rule:MF_00454, ECO:0000256|SAAS:SAAS00573618}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:EGF19828.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AFBE01000002; EGF19828.1; -; Genomic_DNA. DR RefSeq; WP_002917150.1; NZ_GL878559.1. DR EnsemblBacteria; EGF19828; EGF19828; HMPREF9391_0548. DR PATRIC; fig|888818.3.peg.532; -. DR BioCyc; GCF_000195045-HMP:HMPREF9391_RS08860-MONOMER; -. DR Proteomes; UP000004826; Unassembled WGS sequence. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0015103; F:inorganic anion transmembrane transporter activity; IEA:UniProtKB-UniRule. DR HAMAP; MF_00454; CrcB; 1. DR InterPro; IPR003691; CrcB. DR PANTHER; PTHR28259; PTHR28259; 1. DR Pfam; PF02537; CRCB; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702610}; KW Complete proteome {ECO:0000313|Proteomes:UP000004826}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702614}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702612}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702611}; KW Transport {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00096019}. FT TRANSMEM 7 30 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. FT TRANSMEM 36 54 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. FT TRANSMEM 66 85 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. FT TRANSMEM 100 119 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. SQ SEQUENCE 124 AA; 13260 MW; 4D53253598957D72 CRC64; MKEVQNSIAV ALSAMVGGWL RYQIALLLVV ADSFPLGTLL VNYLGTFLLV YIIKGYLSSK VKSQRLILAL STGFCGGLTT FSGLLLDSIK LADSGRYMEL LIYLVLSVGG GLAIALWAGK QVKS //