ID F1RB57_DANRE Unreviewed; 223 AA. AC F1RB57; A0A8M9QEG0; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 2. DT 08-NOV-2023, entry version 68. DE SubName: Full=Amphiregulin {ECO:0000313|Ensembl:ENSDARP00000101371}; DE SubName: Full=Proheparin-binding EGF-like growth factor {ECO:0000313|RefSeq:XP_021332065.1}; GN OrderedLocusNames=areg {ECO:0000313|Ensembl:ENSDARP00000101371, GN ECO:0000313|RefSeq:XP_021332065.1, GN ECO:0000313|ZFIN:ZDB-GENE-141216-239}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000101371}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000101371} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101371}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000101371, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101371}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [3] {ECO:0000313|RefSeq:XP_021332065.1} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_021332065.1}; RG RefSeq; RL Submitted (JUL-2023) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU856358; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009299440.1; XM_009301165.2. DR RefSeq; XP_021332065.1; XM_021476390.1. DR STRING; 7955.ENSDARP00000101371; -. DR Ensembl; ENSDART00000114293.4; ENSDARP00000101371.3; ENSDARG00000076853.4. DR GeneID; 101884611; -. DR KEGG; dre:101884611; -. DR CTD; 374; -. DR ZFIN; ZDB-GENE-141216-239; areg. DR OMA; CSHYRTH; -. DR OrthoDB; 4257137at2759; -. DR Proteomes; UP000000437; Chromosome 5. DR Bgee; ENSDARG00000076853; Expressed in granulocyte and 12 other tissues. DR ExpressionAtlas; F1RB57; baseline and differential. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005154; F:epidermal growth factor receptor binding; IBA:GO_Central. DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central. DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt. DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central. DR GO; GO:0045840; P:positive regulation of mitotic nuclear division; IBA:GO_Central. DR Gene3D; 2.10.25.10; Laminin; 1. DR InterPro; IPR000742; EGF-like_dom. DR PANTHER; PTHR10740:SF16; AMPHIREGULIN; 1. DR PANTHER; PTHR10740; TRANSFORMING GROWTH FACTOR ALPHA; 1. DR SUPFAM; SSF57196; EGF/Laminin; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. PE 4: Predicted; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..223 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5040054424" FT TRANSMEM 171..194 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 113..153 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT REGION 38..114 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 94..114 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 143..152 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" SQ SEQUENCE 223 AA; 24696 MW; 0B06FD2FDF59EAE0 CRC64; MNPQRLSSLL LCVVFTISTA ATHTSVLDHV TVMSSSGEGL QSAVGEDLES DDDQDPSGMF IEPPFFKVTQ ASKGDEQNHK RSGRKKNKGR KRNKNITPVQ PNHTSSHRSR STTADPCLTS HVDYCIHGHC TYLHGLSEPV CVCRRGYDGE RCGIQLLETS RDESSSETTH AALVIMAVVL SVISCLAILI MVCVHYRTHH RFQAAFLSSS NEREKLEKKN IMV //