ID F1RB57_DANRE Unreviewed; 223 AA. AC F1RB57; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 2. DT 25-MAY-2022, entry version 60. DE SubName: Full=Amphiregulin {ECO:0000313|Ensembl:ENSDARP00000101371}; GN Name=areg {ECO:0000313|Ensembl:ENSDARP00000101371, GN ECO:0000313|ZFIN:ZDB-GENE-141216-239}; GN Synonyms=si:ch73-49h18.1 {ECO:0000313|ZFIN:ZDB-GENE-141216-239}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000101371, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000101371} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101371}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000101371, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101371, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU856358; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009299440.1; XM_009301165.2. DR AlphaFoldDB; F1RB57; -. DR STRING; 7955.ENSDARP00000101371; -. DR Ensembl; ENSDART00000114293.4; ENSDARP00000101371.3; ENSDARG00000076853.4. DR GeneID; 101884611; -. DR KEGG; dre:101884611; -. DR CTD; 374; -. DR ZFIN; ZDB-GENE-141216-239; areg. DR GeneTree; ENSGT00940000156901; -. DR InParanoid; F1RB57; -. DR OrthoDB; 1169005at2759; -. DR Reactome; R-DRE-1257604; PIP3 activates AKT signaling. DR Reactome; R-DRE-177929; Signaling by EGFR. DR Reactome; R-DRE-179812; GRB2 events in EGFR signaling. DR Reactome; R-DRE-180292; GAB1 signalosome. DR Reactome; R-DRE-180336; SHC1 events in EGFR signaling. DR Reactome; R-DRE-182971; EGFR downregulation. DR Reactome; R-DRE-204005; COPII-mediated vesicle transport. DR Reactome; R-DRE-212718; EGFR interacts with phospholipase C-gamma. DR Reactome; R-DRE-5673001; RAF/MAP kinase cascade. DR Reactome; R-DRE-5694530; Cargo concentration in the ER. DR Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling. DR Reactome; R-DRE-8856825; Cargo recognition for clathrin-mediated endocytosis. DR Reactome; R-DRE-8856828; Clathrin-mediated endocytosis. DR Reactome; R-DRE-9009391; Extra-nuclear estrogen signaling. DR Proteomes; UP000000437; Chromosome 5. DR Bgee; ENSDARG00000076853; Expressed in granulocyte and 16 other tissues. DR ExpressionAtlas; F1RB57; baseline. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005154; F:epidermal growth factor receptor binding; IBA:GO_Central. DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central. DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt. DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central. DR GO; GO:0045741; P:positive regulation of epidermal growth factor-activated receptor activity; IBA:GO_Central. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR015497; EGF_rcpt_ligand. DR PANTHER; PTHR10740; PTHR10740; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. PE 4: Predicted; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Growth factor {ECO:0000256|ARBA:ARBA00023030}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..223 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5006466238" FT TRANSMEM 171..194 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 113..153 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT REGION 38..114 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 94..114 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 143..152 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" SQ SEQUENCE 223 AA; 24696 MW; 0B06FD2FDF59EAE0 CRC64; MNPQRLSSLL LCVVFTISTA ATHTSVLDHV TVMSSSGEGL QSAVGEDLES DDDQDPSGMF IEPPFFKVTQ ASKGDEQNHK RSGRKKNKGR KRNKNITPVQ PNHTSSHRSR STTADPCLTS HVDYCIHGHC TYLHGLSEPV CVCRRGYDGE RCGIQLLETS RDESSSETTH AALVIMAVVL SVISCLAILI MVCVHYRTHH RFQAAFLSSS NEREKLEKKN IMV //