ID F1RB57_DANRE Unreviewed; 223 AA.
AC F1RB57;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 11-DEC-2019, entry version 53.
DE SubName: Full=Amphiregulin {ECO:0000313|Ensembl:ENSDARP00000101371};
GN Name=areg {ECO:0000313|Ensembl:ENSDARP00000101371,
GN ECO:0000313|ZFIN:ZDB-GENE-141216-239};
GN Synonyms=si:ch73-49h18.1 {ECO:0000313|ZFIN:ZDB-GENE-141216-239};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000101371, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000101371}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101371};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000101371, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101371,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CU856358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_009299440.1; XM_009301165.2.
DR Ensembl; ENSDART00000114293; ENSDARP00000101371; ENSDARG00000076853.
DR GeneID; 101884611; -.
DR KEGG; dre:101884611; -.
DR CTD; 374; -.
DR ZFIN; ZDB-GENE-141216-239; areg.
DR eggNOG; ENOG410IXZG; Eukaryota.
DR eggNOG; ENOG4112CXY; LUCA.
DR GeneTree; ENSGT00940000156901; -.
DR InParanoid; F1RB57; -.
DR OrthoDB; 1169005at2759; -.
DR Reactome; R-DRE-1257604; PIP3 activates AKT signaling.
DR Reactome; R-DRE-177929; Signaling by EGFR.
DR Reactome; R-DRE-179812; GRB2 events in EGFR signaling.
DR Reactome; R-DRE-180292; GAB1 signalosome.
DR Reactome; R-DRE-180336; SHC1 events in EGFR signaling.
DR Reactome; R-DRE-182971; EGFR downregulation.
DR Reactome; R-DRE-204005; COPII-mediated vesicle transport.
DR Reactome; R-DRE-212718; EGFR interacts with phospholipase C-gamma.
DR Reactome; R-DRE-5673001; RAF/MAP kinase cascade.
DR Reactome; R-DRE-5694530; Cargo concentration in the ER.
DR Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Reactome; R-DRE-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-DRE-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-DRE-9009391; Extra-nuclear estrogen signaling.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000076853; Expressed in 10 organ(s), highest expression level in intestine.
DR ExpressionAtlas; F1RB57; baseline.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..223
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006466238"
FT TRANSMEM 171..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..153
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 38..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..114
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 143..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 223 AA; 24696 MW; 0B06FD2FDF59EAE0 CRC64;
MNPQRLSSLL LCVVFTISTA ATHTSVLDHV TVMSSSGEGL QSAVGEDLES DDDQDPSGMF
IEPPFFKVTQ ASKGDEQNHK RSGRKKNKGR KRNKNITPVQ PNHTSSHRSR STTADPCLTS
HVDYCIHGHC TYLHGLSEPV CVCRRGYDGE RCGIQLLETS RDESSSETTH AALVIMAVVL
SVISCLAILI MVCVHYRTHH RFQAAFLSSS NEREKLEKKN IMV
//