ID F1RB57_DANRE Unreviewed; 223 AA. AC F1RB57; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 2. DT 17-FEB-2016, entry version 25. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000101371}; GN Name=si:ch73-49h18.1 {ECO:0000313|Ensembl:ENSDARP00000101371}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000101371, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000101371} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101371}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000101371, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101371, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000101371}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU856358; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_009299440.1; XM_009301165.1. DR STRING; 7955.ENSDARP00000101371; -. DR PaxDb; F1RB57; -. DR Ensembl; ENSDART00000114293; ENSDARP00000101371; ENSDARG00000076853. DR GeneID; 101884611; -. DR ZFIN; ZDB-GENE-141216-239; si:ch73-49h18.1. DR eggNOG; ENOG410IXZG; Eukaryota. DR eggNOG; ENOG4112CXY; LUCA. DR GeneTree; ENSGT00530000063708; -. DR InParanoid; F1RB57; -. DR OrthoDB; EOG7W9RWJ; -. DR Reactome; R-DRE-204005; COPII (Coat Protein 2) Mediated Vesicle Transport. DR Reactome; R-DRE-5694530; Cargo concentration in the ER. DR Proteomes; UP000000437; Chromosome 5. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005154; F:epidermal growth factor receptor binding; IBA:GO_Central. DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central. DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central. DR GO; GO:0008284; P:positive regulation of cell proliferation; IBA:GO_Central. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR015497; EGF_rcpt_ligand. DR PANTHER; PTHR10740; PTHR10740; 1. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 1. DR PROSITE; PS50026; EGF_3; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 223 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5006466238. FT TRANSMEM 171 194 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 113 153 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT COILED 223 223 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 223 AA; 24696 MW; 0B06FD2FDF59EAE0 CRC64; MNPQRLSSLL LCVVFTISTA ATHTSVLDHV TVMSSSGEGL QSAVGEDLES DDDQDPSGMF IEPPFFKVTQ ASKGDEQNHK RSGRKKNKGR KRNKNITPVQ PNHTSSHRSR STTADPCLTS HVDYCIHGHC TYLHGLSEPV CVCRRGYDGE RCGIQLLETS RDESSSETTH AALVIMAVVL SVISCLAILI MVCVHYRTHH RFQAAFLSSS NEREKLEKKN IMV //