ID F1R6L6_DANRE Unreviewed; 705 AA. AC F1R6L6; A0A8M1NB67; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 27-MAR-2024, entry version 80. DE RecName: Full=Nucleolin {ECO:0000256|ARBA:ARBA00017108}; GN Name=ncl {ECO:0000313|Ensembl:ENSDARP00000013803, GN ECO:0000313|RefSeq:NP_001070120.2, GN ECO:0000313|ZFIN:ZDB-GENE-030131-6986}; GN Synonyms=fa12d03 {ECO:0000313|RefSeq:NP_001070120.2}, wu:fa12d03 GN {ECO:0000313|RefSeq:NP_001070120.2}, zgc:152810 GN {ECO:0000313|RefSeq:NP_001070120.2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000013803}; RN [1] {ECO:0000313|RefSeq:NP_001070120.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070120.2}; RX PubMed=16874410; RA Quezada C., Navarro C., San Martin R., Alvarez M., Molina A., Vera M.I.; RT "Genomic organization of nucleolin gene in carp fish: evidence for several RT genes."; RL Biol. Res. 39:353-365(2006). RN [2] {ECO:0000313|RefSeq:NP_001070120.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070120.2}; RX PubMed=17497411; RA Kreiling J.A., Creton R., Reinisch C.; RT "Early embryonic exposure to polychlorinated biphenyls disrupts heat-shock RT protein 70 cognate expression in zebrafish."; RL J. Toxicol. Environ. Health Part A 70:1005-1013(2007). RN [3] {ECO:0000313|RefSeq:NP_001070120.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070120.2}; RX PubMed=21555364; RA Aanes H., Winata C.L., Lin C.H., Chen J.P., Srinivasan K.G., Lee S.G., RA Lim A.Y., Hajan H.S., Collas P., Bourque G., Gong Z., Korzh V., RA Alestrom P., Mathavan S.; RT "Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics RT during maternal to zygotic transition."; RL Genome Res. 21:1328-1338(2011). RN [4] {ECO:0000313|Ensembl:ENSDARP00000013803} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [5] {ECO:0000313|RefSeq:NP_001070120.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070120.2}; RX PubMed=24077883; RA Monte E., Mouillesseaux K., Chen H., Kimball T., Ren S., Wang Y., RA Chen J.N., Vondriska T.M., Franklin S.; RT "Systems proteomics of cardiac chromatin identifies nucleolin as a RT regulator of growth and cellular plasticity in cardiomyocytes."; RL Am. J. Physiol. Heart Circ. Physiol. 305:H1624-H1638(2013). RN [6] {ECO:0000313|Ensembl:ENSDARP00000013803, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803}; RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [7] {ECO:0000313|RefSeq:NP_001070120.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070120.2}; RX PubMed=26469318; RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M., RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D., RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E., RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M., RA Reith W., Hertzano R.; RT "RFX transcription factors are essential for hearing in mice."; RL Nat. Commun. 6:8549-8549(2015). RN [8] {ECO:0000313|RefSeq:NP_001070120.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070120.2}; RX PubMed=28252024; RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A., RA Choudhary J.S., Emes R.D., Grant S.G.; RT "Evolution of complexity in the zebrafish synapse proteome."; RL Nat. Commun. 8:14613-14613(2017). RN [9] {ECO:0000313|RefSeq:NP_001070120.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070120.2}; RX PubMed=29225165; RA Chakraborty A., Uechi T., Nakajima Y., Gazda H.T., O'Donohue M.F., RA Gleizes P.E., Kenmochi N.; RT "Cross talk between TP53 and c-Myc in the pathophysiology of Diamond- RT Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro RT models."; RL Biochem. Biophys. Res. Commun. 495:1839-1845(2018). RN [10] {ECO:0000313|RefSeq:NP_001070120.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070120.2}; RX PubMed=29229769; DOI=10.1242/dev.159566; RA Winata C.L., Lapinski M., Pryszcz L., Vaz C., Bin Ismail M.H., Nama S., RA Hajan H.S., Lee S.G.P., Korzh V., Sampath P., Tanavde V., Mathavan S.; RT "Cytoplasmic polyadenylation-mediated translational control of maternal RT mRNAs directs maternal-to-zygotic transition. ."; RL Development 145:dev159566-dev159566(2018). RN [11] {ECO:0000313|RefSeq:NP_001070120.2} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001070120.2}; RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus CC {ECO:0000256|ARBA:ARBA00004604}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU469540; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CU539057; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001070120.2; NM_001076652.2. DR PaxDb; 7955-ENSDARP00000013803; -. DR Ensembl; ENSDART00000017188; ENSDARP00000013803; ENSDARG00000002710. DR Ensembl; ENSDART00000017188.8; ENSDARP00000013803.6; ENSDARG00000002710.10. DR GeneID; 767714; -. DR KEGG; dre:767714; -. DR AGR; ZFIN:ZDB-GENE-030131-6986; -. DR CTD; 4691; -. DR ZFIN; ZDB-GENE-030131-6986; ncl. DR eggNOG; KOG0118; Eukaryota. DR eggNOG; KOG4210; Eukaryota. DR HOGENOM; CLU_026300_1_0_1; -. DR OMA; YVQYSSV; -. DR OrthoDB; 5482496at2759; -. DR PhylomeDB; F1R6L6; -. DR TreeFam; TF328499; -. DR Proteomes; UP000000437; Chromosome 22. DR Bgee; ENSDARG00000002710; Expressed in gastrula and 28 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central. DR GO; GO:0001947; P:heart looping; IMP:ZFIN. DR GO; GO:0001503; P:ossification; IMP:ZFIN. DR GO; GO:0061035; P:regulation of cartilage development; IMP:ZFIN. DR GO; GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IMP:ZFIN. DR GO; GO:0006364; P:rRNA processing; IMP:ZFIN. DR GO; GO:0009303; P:rRNA transcription; IMP:ZFIN. DR CDD; cd12403; RRM1_NCL; 1. DR CDD; cd12404; RRM2_NCL; 1. DR CDD; cd12405; RRM3_NCL; 1. DR CDD; cd12406; RRM4_NCL; 1. DR Gene3D; 3.30.70.330; -; 4. DR InterPro; IPR034230; Nucleolin_RRM1. DR InterPro; IPR034233; Nucleolin_RRM2. DR InterPro; IPR034234; Nucleolin_RRM3. DR InterPro; IPR034235; Nucleolin_RRM4. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR000504; RRM_dom. DR PANTHER; PTHR48025; OS02G0815200 PROTEIN; 1. DR PANTHER; PTHR48025:SF22; OS02G0815200 PROTEIN; 1. DR Pfam; PF00076; RRM_1; 4. DR SMART; SM00360; RRM; 4. DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4. DR PROSITE; PS50102; RRM; 4. PE 1: Evidence at protein level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Methylation {ECO:0000256|ARBA:ARBA00022481}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Proteomics identification {ECO:0007829|PeptideAtlas:F1R6L6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE- KW ProRule:PRU00176}. FT DOMAIN 287..363 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT DOMAIN 377..451 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT DOMAIN 465..538 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT DOMAIN 554..629 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT REGION 1..286 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 625..705 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..25 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 26..42 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 70..84 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 112..127 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 161..175 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 199..218 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 219..236 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 237..256 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 257..279 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 705 AA; 75061 MW; 9D184974F3967733 CRC64; MVKLAKAAKK DAPPKKKAPP PPKEVEEESS EEDSDDDEEE EAPPVKAVAK KNAAPVKAVK NGKAAAKQES EDEDDDDEDD ESEEEAPPPK KAAKAPAKAA APAKKAAPAE ESSEEDDDDD DDDESEEEAP PPKKAPAKAT PAKATPAKKA APVKKAAPAE ESEDDDDDED ESEEEEAPPP KKAAAAAKPA AKAPAAKEES DEEEDDDEEE DDSEEEEMDT TPAPKAKKAG MVKAKEESEE EDDDDEEDDD DEEEEETPAT PAKRKAETKK EKGTPPAKKA KTDGEGFSLF LGNLNNNKDF DELKSAISKF FSKEGLEIQD VRLGGTKKFG YVDFASEEEL QKALELNGKK LLGQPVKLDK ARSKENSQEN KKERDARTLF VKNLPYSITQ DDLREIFDQA VDIRVPMGNT GTSRGIAYIE FKTEAIAEKA LEEAQGSDVQ GRSIIVDFTG DKSRQGGRGA PSASKVLVVN NLAFSASEDS LQSVFEKAVS IRIPQNNGRP KGYAFVEFEN VEDSKEALEN CNNTDIEGRS IRLEYSQNDR ERGGGGRGNS GPTKTLFVKG LSDDTTDQTL KDSFDGAIAA RIATDRDTGS SKGFGFVDFD NEQDCKAAKE AMDDGEIDGN KVTLDYAKPK GEGGRGGFGG GRGGFGGRGG GRGGFGGRGG GGRGGGFRGG RGGRGGGGGF RGGRGGGGRG GFGDRPQGKK IKFDD //