ID F1R6L6_DANRE Unreviewed; 705 AA. AC F1R6L6; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 03-AUG-2022, entry version 71. DE RecName: Full=Nucleolin {ECO:0000256|ARBA:ARBA00017108}; GN OrderedLocusNames=ncl {ECO:0000313|Ensembl:ENSDARP00000013803, GN ECO:0000313|ZFIN:ZDB-GENE-030131-6986}; GN ORFNames=SO:0001217 {ECO:0000313|ZFIN:ZDB-GENE-030131-6986}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000013803}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000013803} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000013803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus CC {ECO:0000256|ARBA:ARBA00004604}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU469540; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CU539057; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001070120.2; NM_001076652.2. DR AlphaFoldDB; F1R6L6; -. DR SMR; F1R6L6; -. DR STRING; 7955.ENSDARP00000013803; -. DR PaxDb; F1R6L6; -. DR Ensembl; ENSDART00000017188.8; ENSDARP00000013803.6; ENSDARG00000002710.10. DR GeneID; 767714; -. DR KEGG; dre:767714; -. DR CTD; 4691; -. DR ZFIN; ZDB-GENE-030131-6986; ncl. DR ZFIN; ZDB-GENE-030131-6986; SO:0001217. DR eggNOG; KOG0118; Eukaryota. DR eggNOG; KOG4210; Eukaryota. DR GeneTree; ENSGT00940000163473; -. DR HOGENOM; CLU_026300_1_0_1; -. DR InParanoid; F1R6L6; -. DR OMA; GYVQYSS; -. DR OrthoDB; 1174365at2759; -. DR PhylomeDB; F1R6L6; -. DR TreeFam; TF328499; -. DR Proteomes; UP000814640; Chromosome 22. DR Bgee; ENSDARG00000002710; Expressed in gastrula and 28 other tissues. DR ExpressionAtlas; F1R6L6; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central. DR GO; GO:0001947; P:heart looping; IMP:ZFIN. DR GO; GO:0006364; P:rRNA processing; IMP:ZFIN. DR GO; GO:0009303; P:rRNA transcription; IMP:ZFIN. DR CDD; cd12403; RRM1_NCL; 1. DR CDD; cd12405; RRM3_NCL; 1. DR CDD; cd12406; RRM4_NCL; 1. DR Gene3D; 3.30.70.330; -; 4. DR InterPro; IPR034230; Nucleolin_RRM1. DR InterPro; IPR034234; Nucleolin_RRM3. DR InterPro; IPR034235; Nucleolin_RRM4. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR000504; RRM_dom. DR Pfam; PF00076; RRM_1; 4. DR SMART; SM00360; RRM; 4. DR SUPFAM; SSF54928; SSF54928; 4. DR PROSITE; PS50102; RRM; 4. PE 1: Evidence at protein level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Methylation {ECO:0000256|ARBA:ARBA00022481}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Proteomics identification {ECO:0007829|PeptideAtlas:F1R6L6}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}. FT DOMAIN 287..363 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT DOMAIN 377..451 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT DOMAIN 465..538 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT DOMAIN 554..629 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT REGION 1..286 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 625..705 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..25 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 26..42 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 70..84 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 112..127 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 161..175 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 199..218 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 219..236 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 237..256 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 257..279 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 705 AA; 75061 MW; 9D184974F3967733 CRC64; MVKLAKAAKK DAPPKKKAPP PPKEVEEESS EEDSDDDEEE EAPPVKAVAK KNAAPVKAVK NGKAAAKQES EDEDDDDEDD ESEEEAPPPK KAAKAPAKAA APAKKAAPAE ESSEEDDDDD DDDESEEEAP PPKKAPAKAT PAKATPAKKA APVKKAAPAE ESEDDDDDED ESEEEEAPPP KKAAAAAKPA AKAPAAKEES DEEEDDDEEE DDSEEEEMDT TPAPKAKKAG MVKAKEESEE EDDDDEEDDD DEEEEETPAT PAKRKAETKK EKGTPPAKKA KTDGEGFSLF LGNLNNNKDF DELKSAISKF FSKEGLEIQD VRLGGTKKFG YVDFASEEEL QKALELNGKK LLGQPVKLDK ARSKENSQEN KKERDARTLF VKNLPYSITQ DDLREIFDQA VDIRVPMGNT GTSRGIAYIE FKTEAIAEKA LEEAQGSDVQ GRSIIVDFTG DKSRQGGRGA PSASKVLVVN NLAFSASEDS LQSVFEKAVS IRIPQNNGRP KGYAFVEFEN VEDSKEALEN CNNTDIEGRS IRLEYSQNDR ERGGGGRGNS GPTKTLFVKG LSDDTTDQTL KDSFDGAIAA RIATDRDTGS SKGFGFVDFD NEQDCKAAKE AMDDGEIDGN KVTLDYAKPK GEGGRGGFGG GRGGFGGRGG GRGGFGGRGG GGRGGGFRGG RGGRGGGGGF RGGRGGGGRG GFGDRPQGKK IKFDD //