ID F1R6L6_DANRE Unreviewed; 705 AA. AC F1R6L6; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 16-OCT-2019, entry version 59. DE SubName: Full=Nucleolin {ECO:0000313|Ensembl:ENSDARP00000013803}; GN Name=ncl {ECO:0000313|Ensembl:ENSDARP00000013803, GN ECO:0000313|ZFIN:ZDB-GENE-030131-6986}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000013803, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000013803} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000013803, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU469540; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CU539057; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001070120.2; NM_001076652.2. DR STRING; 7955.ENSDARP00000013803; -. DR PaxDb; F1R6L6; -. DR Ensembl; ENSDART00000017188; ENSDARP00000013803; ENSDARG00000002710. DR GeneID; 767714; -. DR KEGG; dre:767714; -. DR CTD; 4691; -. DR ZFIN; ZDB-GENE-030131-6986; ncl. DR eggNOG; KOG0123; Eukaryota. DR eggNOG; ENOG410XR5X; LUCA. DR GeneTree; ENSGT00940000163473; -. DR InParanoid; F1R6L6; -. DR KO; K11294; -. DR OMA; DGNFRGF; -. DR OrthoDB; 1174365at2759; -. DR TreeFam; TF328499; -. DR Proteomes; UP000000437; Chromosome 22. DR Bgee; ENSDARG00000002710; Expressed in 29 organ(s), highest expression level in gastrula. DR ExpressionAtlas; F1R6L6; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central. DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central. DR GO; GO:0001947; P:heart looping; IMP:ZFIN. DR GO; GO:0006364; P:rRNA processing; IMP:ZFIN. DR GO; GO:0009303; P:rRNA transcription; IMP:ZFIN. DR CDD; cd12403; RRM1_NCL; 1. DR CDD; cd12404; RRM2_NCL; 1. DR CDD; cd12405; RRM3_NCL; 1. DR CDD; cd12406; RRM4_NCL; 1. DR Gene3D; 3.30.70.330; -; 4. DR InterPro; IPR034230; Nucleolin_RRM1. DR InterPro; IPR034233; Nucleolin_RRM2. DR InterPro; IPR034234; Nucleolin_RRM3. DR InterPro; IPR034235; Nucleolin_RRM4. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR000504; RRM_dom. DR Pfam; PF00076; RRM_1; 4. DR SMART; SM00360; RRM; 4. DR SUPFAM; SSF54928; SSF54928; 4. DR PROSITE; PS50102; RRM; 4. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1R6L6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}. FT DOMAIN 287 363 RRM. {ECO:0000259|PROSITE:PS50102}. FT DOMAIN 377 451 RRM. {ECO:0000259|PROSITE:PS50102}. FT DOMAIN 465 538 RRM. {ECO:0000259|PROSITE:PS50102}. FT DOMAIN 554 629 RRM. {ECO:0000259|PROSITE:PS50102}. FT REGION 1 286 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 625 705 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 1 25 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 26 42 Acidic. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 70 84 Acidic. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 112 127 Acidic. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 161 175 Acidic. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 199 218 Acidic. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 219 236 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 237 256 Acidic. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 257 279 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. SQ SEQUENCE 705 AA; 75061 MW; 9D184974F3967733 CRC64; MVKLAKAAKK DAPPKKKAPP PPKEVEEESS EEDSDDDEEE EAPPVKAVAK KNAAPVKAVK NGKAAAKQES EDEDDDDEDD ESEEEAPPPK KAAKAPAKAA APAKKAAPAE ESSEEDDDDD DDDESEEEAP PPKKAPAKAT PAKATPAKKA APVKKAAPAE ESEDDDDDED ESEEEEAPPP KKAAAAAKPA AKAPAAKEES DEEEDDDEEE DDSEEEEMDT TPAPKAKKAG MVKAKEESEE EDDDDEEDDD DEEEEETPAT PAKRKAETKK EKGTPPAKKA KTDGEGFSLF LGNLNNNKDF DELKSAISKF FSKEGLEIQD VRLGGTKKFG YVDFASEEEL QKALELNGKK LLGQPVKLDK ARSKENSQEN KKERDARTLF VKNLPYSITQ DDLREIFDQA VDIRVPMGNT GTSRGIAYIE FKTEAIAEKA LEEAQGSDVQ GRSIIVDFTG DKSRQGGRGA PSASKVLVVN NLAFSASEDS LQSVFEKAVS IRIPQNNGRP KGYAFVEFEN VEDSKEALEN CNNTDIEGRS IRLEYSQNDR ERGGGGRGNS GPTKTLFVKG LSDDTTDQTL KDSFDGAIAA RIATDRDTGS SKGFGFVDFD NEQDCKAAKE AMDDGEIDGN KVTLDYAKPK GEGGRGGFGG GRGGFGGRGG GRGGFGGRGG GGRGGGFRGG RGGRGGGGGF RGGRGGGGRG GFGDRPQGKK IKFDD //