ID F1R6L6_DANRE Unreviewed; 705 AA. AC F1R6L6; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 07-NOV-2018, entry version 53. DE SubName: Full=Nucleolin {ECO:0000313|Ensembl:ENSDARP00000013803}; GN Name=ncl {ECO:0000313|Ensembl:ENSDARP00000013803, GN ECO:0000313|ZFIN:ZDB-GENE-030131-6986}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000013803, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000013803} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000013803, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU469540; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CU539057; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001070120.2; NM_001076652.2. DR UniGene; Dr.75207; -. DR STRING; 7955.ENSDARP00000013803; -. DR PaxDb; F1R6L6; -. DR Ensembl; ENSDART00000017188; ENSDARP00000013803; ENSDARG00000002710. DR GeneID; 767714; -. DR KEGG; dre:767714; -. DR CTD; 4691; -. DR ZFIN; ZDB-GENE-030131-6986; ncl. DR eggNOG; KOG0123; Eukaryota. DR eggNOG; ENOG410XR5X; LUCA. DR GeneTree; ENSGT00900000141052; -. DR InParanoid; F1R6L6; -. DR KO; K11294; -. DR OMA; DMESDEP; -. DR OrthoDB; EOG091G15MK; -. DR TreeFam; TF328499; -. DR Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol. DR Proteomes; UP000000437; Chromosome 22. DR Bgee; ENSDARG00000002710; Expressed in 29 organ(s), highest expression level in gastrula. DR ExpressionAtlas; F1R6L6; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central. DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central. DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central. DR GO; GO:0001947; P:heart looping; IMP:ZFIN. DR GO; GO:2000815; P:regulation of mRNA stability involved in response to oxidative stress; IBA:GO_Central. DR GO; GO:0006364; P:rRNA processing; IMP:ZFIN. DR GO; GO:0009303; P:rRNA transcription; IMP:ZFIN. DR CDD; cd12403; RRM1_NCL; 1. DR CDD; cd12404; RRM2_NCL; 1. DR CDD; cd12405; RRM3_NCL; 1. DR CDD; cd12406; RRM4_NCL; 1. DR Gene3D; 3.30.70.330; -; 4. DR InterPro; IPR034230; Nucleolin_RRM1. DR InterPro; IPR034233; Nucleolin_RRM2. DR InterPro; IPR034234; Nucleolin_RRM3. DR InterPro; IPR034235; Nucleolin_RRM4. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR000504; RRM_dom. DR Pfam; PF00076; RRM_1; 4. DR SMART; SM00360; RRM; 4. DR SUPFAM; SSF54928; SSF54928; 4. DR PROSITE; PS50102; RRM; 4. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1R6L6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}. FT DOMAIN 287 363 RRM. {ECO:0000259|PROSITE:PS50102}. FT DOMAIN 377 451 RRM. {ECO:0000259|PROSITE:PS50102}. FT DOMAIN 465 538 RRM. {ECO:0000259|PROSITE:PS50102}. FT DOMAIN 554 629 RRM. {ECO:0000259|PROSITE:PS50102}. SQ SEQUENCE 705 AA; 75061 MW; 9D184974F3967733 CRC64; MVKLAKAAKK DAPPKKKAPP PPKEVEEESS EEDSDDDEEE EAPPVKAVAK KNAAPVKAVK NGKAAAKQES EDEDDDDEDD ESEEEAPPPK KAAKAPAKAA APAKKAAPAE ESSEEDDDDD DDDESEEEAP PPKKAPAKAT PAKATPAKKA APVKKAAPAE ESEDDDDDED ESEEEEAPPP KKAAAAAKPA AKAPAAKEES DEEEDDDEEE DDSEEEEMDT TPAPKAKKAG MVKAKEESEE EDDDDEEDDD DEEEEETPAT PAKRKAETKK EKGTPPAKKA KTDGEGFSLF LGNLNNNKDF DELKSAISKF FSKEGLEIQD VRLGGTKKFG YVDFASEEEL QKALELNGKK LLGQPVKLDK ARSKENSQEN KKERDARTLF VKNLPYSITQ DDLREIFDQA VDIRVPMGNT GTSRGIAYIE FKTEAIAEKA LEEAQGSDVQ GRSIIVDFTG DKSRQGGRGA PSASKVLVVN NLAFSASEDS LQSVFEKAVS IRIPQNNGRP KGYAFVEFEN VEDSKEALEN CNNTDIEGRS IRLEYSQNDR ERGGGGRGNS GPTKTLFVKG LSDDTTDQTL KDSFDGAIAA RIATDRDTGS SKGFGFVDFD NEQDCKAAKE AMDDGEIDGN KVTLDYAKPK GEGGRGGFGG GRGGFGGRGG GRGGFGGRGG GGRGGGFRGG RGGRGGGGGF RGGRGGGGRG GFGDRPQGKK IKFDD //