ID   F1R6L6_DANRE            Unreviewed;       705 AA.
AC   F1R6L6;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   23-MAY-2018, entry version 51.
DE   SubName: Full=Nucleolin {ECO:0000313|Ensembl:ENSDARP00000013803};
GN   Name=ncl {ECO:0000313|Ensembl:ENSDARP00000013803,
GN   ECO:0000313|ZFIN:ZDB-GENE-030131-6986};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000013803, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000013803}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000013803, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000013803,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
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DR   EMBL; CU469540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU539057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001070120.2; NM_001076652.2.
DR   UniGene; Dr.75207; -.
DR   STRING; 7955.ENSDARP00000013803; -.
DR   PaxDb; F1R6L6; -.
DR   Ensembl; ENSDART00000017188; ENSDARP00000013803; ENSDARG00000002710.
DR   GeneID; 767714; -.
DR   KEGG; dre:767714; -.
DR   CTD; 4691; -.
DR   ZFIN; ZDB-GENE-030131-6986; ncl.
DR   eggNOG; KOG0123; Eukaryota.
DR   eggNOG; ENOG410XR5X; LUCA.
DR   GeneTree; ENSGT00900000141052; -.
DR   InParanoid; F1R6L6; -.
DR   KO; K11294; -.
DR   OMA; DMESDEP; -.
DR   OrthoDB; EOG091G15MK; -.
DR   TreeFam; TF328499; -.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Proteomes; UP000000437; Chromosome 22.
DR   Bgee; ENSDARG00000002710; -.
DR   ExpressionAtlas; F1R6L6; baseline and differential.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR   GO; GO:0006364; P:rRNA processing; IMP:ZFIN.
DR   GO; GO:0009303; P:rRNA transcription; IMP:ZFIN.
DR   CDD; cd12403; RRM1_NCL; 1.
DR   CDD; cd12404; RRM2_NCL; 1.
DR   CDD; cd12405; RRM3_NCL; 1.
DR   CDD; cd12406; RRM4_NCL; 1.
DR   Gene3D; 3.30.70.330; -; 4.
DR   InterPro; IPR034230; Nucleolin_RRM1.
DR   InterPro; IPR034233; Nucleolin_RRM2.
DR   InterPro; IPR034234; Nucleolin_RRM3.
DR   InterPro; IPR034235; Nucleolin_RRM4.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 4.
DR   SMART; SM00360; RRM; 4.
DR   SUPFAM; SSF54928; SSF54928; 4.
DR   PROSITE; PS50102; RRM; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F1R6L6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN      287    363       RRM. {ECO:0000259|PROSITE:PS50102}.
FT   DOMAIN      377    451       RRM. {ECO:0000259|PROSITE:PS50102}.
FT   DOMAIN      465    538       RRM. {ECO:0000259|PROSITE:PS50102}.
FT   DOMAIN      554    629       RRM. {ECO:0000259|PROSITE:PS50102}.
SQ   SEQUENCE   705 AA;  75061 MW;  9D184974F3967733 CRC64;
     MVKLAKAAKK DAPPKKKAPP PPKEVEEESS EEDSDDDEEE EAPPVKAVAK KNAAPVKAVK
     NGKAAAKQES EDEDDDDEDD ESEEEAPPPK KAAKAPAKAA APAKKAAPAE ESSEEDDDDD
     DDDESEEEAP PPKKAPAKAT PAKATPAKKA APVKKAAPAE ESEDDDDDED ESEEEEAPPP
     KKAAAAAKPA AKAPAAKEES DEEEDDDEEE DDSEEEEMDT TPAPKAKKAG MVKAKEESEE
     EDDDDEEDDD DEEEEETPAT PAKRKAETKK EKGTPPAKKA KTDGEGFSLF LGNLNNNKDF
     DELKSAISKF FSKEGLEIQD VRLGGTKKFG YVDFASEEEL QKALELNGKK LLGQPVKLDK
     ARSKENSQEN KKERDARTLF VKNLPYSITQ DDLREIFDQA VDIRVPMGNT GTSRGIAYIE
     FKTEAIAEKA LEEAQGSDVQ GRSIIVDFTG DKSRQGGRGA PSASKVLVVN NLAFSASEDS
     LQSVFEKAVS IRIPQNNGRP KGYAFVEFEN VEDSKEALEN CNNTDIEGRS IRLEYSQNDR
     ERGGGGRGNS GPTKTLFVKG LSDDTTDQTL KDSFDGAIAA RIATDRDTGS SKGFGFVDFD
     NEQDCKAAKE AMDDGEIDGN KVTLDYAKPK GEGGRGGFGG GRGGFGGRGG GRGGFGGRGG
     GGRGGGFRGG RGGRGGGGGF RGGRGGGGRG GFGDRPQGKK IKFDD
//