ID F1R506_DANRE Unreviewed; 721 AA. AC F1R506; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 16-SEP-2015, entry version 36. DE RecName: Full=Protein kinase C {ECO:0000256|PIRNR:PIRNR000551, ECO:0000256|SAAS:SAAS00253193}; DE EC=2.7.11.13 {ECO:0000256|PIRNR:PIRNR000551, ECO:0000256|SAAS:SAAS00253193}; GN Name=prkcq {ECO:0000313|Ensembl:ENSDARP00000046252, GN ECO:0000313|ZFIN:ZDB-GENE-041210-195}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000046252, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000046252} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046252}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000046252, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000046252, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC {ECO:0000256|PIRNR:PIRNR000551, ECO:0000256|SAAS:SAAS00263344}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr CC protein kinase family. PKC subfamily. CC {ECO:0000256|PIRNR:PIRNR000551}. CC -!- SIMILARITY: Contains AGC-kinase C-terminal domain. CC {ECO:0000256|SAAS:SAAS00128355}. CC -!- SIMILARITY: Contains protein kinase domain. CC {ECO:0000256|SAAS:SAAS00105938}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000046252}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL954652; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F1R506; -. DR STRING; 7955.ENSDARP00000046252; -. DR Ensembl; ENSDART00000046253; ENSDARP00000046252; ENSDARG00000034173. DR ZFIN; ZDB-GENE-041210-195; prkcq. DR InParanoid; F1R506; -. DR OMA; REPQGIS; -. DR TreeFam; TF102004; -. DR Reactome; R-DRE-111465; Apoptotic cleavage of cellular proteins. DR Reactome; R-DRE-114508; Effects of PIP2 hydrolysis. DR Reactome; R-DRE-202424; Downstream TCR signaling. DR Reactome; R-DRE-2514859; Inactivation, recovery and regulation of the phototransduction cascade. DR Reactome; R-DRE-2871837; FCERI mediated NF-kB activation. DR Reactome; R-DRE-373752; Netrin-1 signaling. DR PRO; PR:F1R506; -. DR Proteomes; UP000000437; Chromosome 4. DR Bgee; F1R506; -. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004697; F:protein kinase C activity; IEA:UniProtKB-EC. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR Gene3D; 2.60.40.150; -; 1. DR InterPro; IPR000961; AGC-kinase_C. DR InterPro; IPR000008; C2_dom. DR InterPro; IPR020454; DAG/PE-bd. DR InterPro; IPR011009; Kinase-like_dom. DR InterPro; IPR002219; PE/DAG-bd. DR InterPro; IPR027264; PKC_theta. DR InterPro; IPR017892; Pkinase_C. DR InterPro; IPR014376; Prot_kin_PKC_delta. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR PANTHER; PTHR24352:SF43; PTHR24352:SF43; 1. DR Pfam; PF00130; C1_1; 2. DR Pfam; PF00069; Pkinase; 1. DR Pfam; PF00433; Pkinase_C; 1. DR PIRSF; PIRSF000551; PKC_delta; 1. DR PRINTS; PR00008; DAGPEDOMAIN. DR SMART; SM00109; C1; 2. DR SMART; SM00133; S_TK_X; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF49562; SSF49562; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR PROSITE; PS51285; AGC_KINASE_CTER; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. DR PROSITE; PS00479; ZF_DAG_PE_1; 2. DR PROSITE; PS50081; ZF_DAG_PE_2; 2. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|RuleBase:RU000304, KW ECO:0000256|SAAS:SAAS00128419}; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Kinase {ECO:0000256|PIRNR:PIRNR000551, ECO:0000256|SAAS:SAAS00128365}; KW Metal-binding {ECO:0000256|SAAS:SAAS00253054}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU000304, KW ECO:0000256|SAAS:SAAS00128193}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Serine/threonine-protein kinase {ECO:0000256|PIRNR:PIRNR000551, KW ECO:0000256|SAAS:SAAS00128360}; KW Transferase {ECO:0000256|PIRNR:PIRNR000551, KW ECO:0000256|SAAS:SAAS00128072}; Zinc {ECO:0000256|SAAS:SAAS00253075}; KW Zinc-finger {ECO:0000256|SAAS:SAAS00128318}. SQ SEQUENCE 721 AA; 82598 MW; 7904C3F83EC660C1 CRC64; MSPFLRIAFS SFEMDPGLAY HEEVLNPYCA VYMKEAVENL CASLEKGQVY KQKRPTMYPP WSSTFDAHVH KGRVMHVVVK DKTAELKTEA TVQLDTLASR CKKENGKLEI WVELKPQGRL LMEARYFLER SGHGEGDGET EREKEGVFAL HHRRGAIKQA KVHVVKCHEF TATFFPQPTF CSVCKEFVWG LNKQGYQCRQ CNAAIHKKCI DKVIAKCTGS AVNSKETMIH KERFKIDMPH RFKVYNYMSP TFCEHCGTLL WGLARQGLKC EECGMNVHHK CQKKVANLCG VNQKLMAEAL AMIESTQQQA RSSRDTETVG REGPVSADQP GVIREPSGRL AISPLTPAPP LPRKEHQGIS WDSPADGRRP SLEEPEPLYA TPRKEHHKFT IDSFILHKML GKGSFGKVFL AELKGSGQFF AVKALKKDVV LMDDDVECTM VERRVLSLAW DHPFLTHLYC TFQTKENLFF VMEYLNGGDL MFHIQTCHRF DLPRSTFYAA EIICGLQFLH SKGIVYRDLK LDNILLDTDG HIKIADFGMC KENIIGEART CTFCGTPDYI APEILLGQKY GTSVDWWSFG VLLYEMLIGQ SPFHGHDEEE LFQSIRTDDP CYPRWLTRDA RDILVKLFVR EPERRLGVKG NIRQHPFFRE TDWSALEERQ VEPPFKPTVK SANDCSNFDK EFINEKPRLS VTDRMMINSM DQSMFENFSF INPIMTRLKS P //