ID F1QUU0_DANRE Unreviewed; 464 AA. AC F1QUU0; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 05-JUL-2017, entry version 45. DE SubName: Full=Hexosaminidase B (beta polypeptide) {ECO:0000313|Ensembl:ENSDARP00000088748}; GN Name=hexb {ECO:0000313|Ensembl:ENSDARP00000088748, GN ECO:0000313|ZFIN:ZDB-GENE-030131-2333}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000088748, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000088748} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000088748}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000088748, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000088748, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000088748}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FP016255; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001296792.1; NM_001309863.1. DR UniGene; Dr.5384; -. DR PaxDb; F1QUU0; -. DR Ensembl; ENSDART00000097975; ENSDARP00000088748; ENSDARG00000034368. DR GeneID; 323613; -. DR KEGG; dre:323613; -. DR CTD; 3074; -. DR ZFIN; ZDB-GENE-030131-2333; hexb. DR eggNOG; KOG2499; Eukaryota. DR eggNOG; COG3525; LUCA. DR GeneTree; ENSGT00390000008107; -. DR KO; K12373; -. DR Reactome; R-DRE-1660662; Glycosphingolipid metabolism. DR Reactome; R-DRE-2022857; Keratan sulfate degradation. DR Reactome; R-DRE-2024101; CS/DS degradation. DR Reactome; R-DRE-2160916; Hyaluronan uptake and degradation. DR Reactome; R-DRE-6798695; Neutrophil degranulation. DR Proteomes; UP000000437; Chromosome 5. DR Bgee; ENSDARG00000034368; -. DR ExpressionAtlas; F1QUU0; baseline and differential. DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:InterPro. DR GO; GO:0001525; P:angiogenesis; IMP:ZFIN. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub. DR InterPro; IPR029018; Chitobiase/Hex_dom_2-like. DR InterPro; IPR015883; Glyco_hydro_20_cat. DR InterPro; IPR017853; Glycoside_hydrolase_SF. DR InterPro; IPR029019; HEX_eukaryotic_N. DR Pfam; PF00728; Glyco_hydro_20; 1. DR Pfam; PF14845; Glycohydro_20b2; 1. DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk_; 1. DR PRINTS; PR00738; GLHYDRLASE20. DR SUPFAM; SSF51445; SSF51445; 1. DR SUPFAM; SSF55545; SSF55545; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1QUU0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 464 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003273202. FT DOMAIN 37 160 Glycohydro_20b2. {ECO:0000259|Pfam: FT PF14845}. FT DOMAIN 182 449 Glyco_hydro_20. {ECO:0000259|Pfam: FT PF00728}. FT ACT_SITE 338 338 Proton donor. {ECO:0000256|PIRSR: FT PIRSR001093-1}. SQ SEQUENCE 464 AA; 52966 MW; 139FFD70A53A4066 CRC64; MLCLLKFTPL FLVVAVCHGW LFGDLFEKQK ELDEISLWPL PQKYQSSAVA FKLSAASFQI VHAKQSTAGP SCSLLENAFR RYFEYMFGEL KRQEKSRKKA FDSDLSELQV WITSADPECD GYPSLRTDES YSLSVDETSA VLKAANVWGA LRGLETFSQL VYEDDYGVRN INKTDISDFP RFAHRGILLD SSRHFLPLKV ILANLEAMAM NKFNVFHWHI VDDPSFPFMS RTFPELSQKG AYHPFTHVYT PSDVKMVIEF ARMRGIRVVA EFDTPGHTQS WGNGIKDLLT PCYSGSSPSG SFGPVNPILN SSYEFMAQLF KEISTVFPDA YIHLGGDEVD FSCWKSNPDI QKFMNQQGFG TDYSKLESFY IQRLLDIVAA TKKGYMVWQE VFDNGVKLKD DTVVEVWKGN DMKEELQNVT GAGFTTILSA PWYLDYISYG QDWQRYYKVE PLDFTGQFLQ SNSF //