ID F1QG85_DANRE Unreviewed; 798 AA. AC F1QG85; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 13-NOV-2019, entry version 75. DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633}; GN Name=itgb1a {ECO:0000313|Ensembl:ENSDARP00000039699, GN ECO:0000313|ZFIN:ZDB-GENE-060803-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000039699, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000039699} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000039699}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000039699, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000039699, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. CC {ECO:0000256|SAAS:SAAS01130156}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000633}; CC Single-pass type I membrane protein CC {ECO:0000256|RuleBase:RU000633}. CC -!- SIMILARITY: Belongs to the integrin beta chain family. CC {ECO:0000256|RuleBase:RU000633}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX322549; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005170669.1; XM_005170612.3. DR STRING; 7955.ENSDARP00000039699; -. DR PaxDb; F1QG85; -. DR PRIDE; F1QG85; -. DR Ensembl; ENSDART00000039700; ENSDARP00000039699; ENSDARG00000071863. DR GeneID; 556734; -. DR CTD; 556734; -. DR ZFIN; ZDB-GENE-060803-2; itgb1a. DR eggNOG; KOG1226; Eukaryota. DR eggNOG; ENOG410XP60; LUCA. DR GeneTree; ENSGT00960000186593; -. DR OMA; DEQMCTF; -. DR OrthoDB; 473040at2759; -. DR TreeFam; TF105392; -. DR Proteomes; UP000000437; Chromosome 24. DR Bgee; ENSDARG00000071863; Expressed in 20 organ(s), highest expression level in liver. DR ExpressionAtlas; F1QG85; baseline. DR GO; GO:0008305; C:integrin complex; IEA:InterPro. DR GO; GO:0001968; F:fibronectin binding; IGI:ZFIN. DR GO; GO:0005178; F:integrin binding; IBA:GO_Central. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:ZFIN. DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro. DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central. DR GO; GO:0016477; P:cell migration; IBA:GO_Central. DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central. DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central. DR GO; GO:1903672; P:positive regulation of sprouting angiogenesis; IMP:ZFIN. DR Gene3D; 3.40.50.410; -; 1. DR InterPro; IPR013111; EGF_extracell. DR InterPro; IPR040622; I-EGF_1. DR InterPro; IPR027071; Integrin_beta-1. DR InterPro; IPR033760; Integrin_beta_N. DR InterPro; IPR015812; Integrin_bsu. DR InterPro; IPR014836; Integrin_bsu_cyt_dom. DR InterPro; IPR012896; Integrin_bsu_tail. DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf. DR InterPro; IPR002369; Integrin_bsu_VWA. DR InterPro; IPR032695; Integrin_dom_sf. DR InterPro; IPR016201; PSI. DR InterPro; IPR036465; vWFA_dom_sf. DR PANTHER; PTHR10082; PTHR10082; 1. DR PANTHER; PTHR10082:SF28; PTHR10082:SF28; 1. DR Pfam; PF07974; EGF_2; 1. DR Pfam; PF18372; I-EGF_1; 1. DR Pfam; PF08725; Integrin_b_cyt; 1. DR Pfam; PF07965; Integrin_B_tail; 1. DR Pfam; PF00362; Integrin_beta; 1. DR Pfam; PF17205; PSI_integrin; 1. DR PIRSF; PIRSF002512; Integrin_B; 1. DR PRINTS; PR01186; INTEGRINB. DR SMART; SM00187; INB; 1. DR SMART; SM01241; Integrin_b_cyt; 1. DR SMART; SM01242; Integrin_B_tail; 1. DR SMART; SM00423; PSI; 1. DR SUPFAM; SSF53300; SSF53300; 1. DR SUPFAM; SSF69179; SSF69179; 1. DR SUPFAM; SSF69687; SSF69687; 1. DR PROSITE; PS00243; INTEGRIN_BETA; 1. PE 1: Evidence at protein level; KW Cell adhesion {ECO:0000256|RuleBase:RU000633, KW ECO:0000256|SAAS:SAAS00895049}; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1}; KW Integrin {ECO:0000256|RuleBase:RU000633, KW ECO:0000256|SAAS:SAAS00895071}; KW Membrane {ECO:0000256|SAAS:SAAS01101070, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1QG85}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|RuleBase:RU000633, KW ECO:0000256|SAAS:SAAS00897361, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00895947, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 798 Integrin beta. {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5009954137. FT TRANSMEM 729 751 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 26 76 PSI. {ECO:0000259|SMART:SM00423}. FT DOMAIN 34 464 INB. {ECO:0000259|SMART:SM00187}. FT DOMAIN 640 728 Integrin_B_tail. {ECO:0000259|SMART: FT SM01242}. FT DOMAIN 752 798 Integrin_b_cyt. {ECO:0000259|SMART: FT SM01241}. FT DISULFID 27 464 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 35 45 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 38 75 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 48 64 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 206 212 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 260 300 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 400 414 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 434 691 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 462 466 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 477 489 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 486 525 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 491 500 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 502 516 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 531 536 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 533 568 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 538 553 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 555 560 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 574 579 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 576 607 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 581 590 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 592 599 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 613 618 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 615 661 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 620 630 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 633 636 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 640 649 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 646 723 {ECO:0000256|PIRSR:PIRSR002512-1}. FT DISULFID 665 699 {ECO:0000256|PIRSR:PIRSR002512-1}. SQ SEQUENCE 798 AA; 88617 MW; E94A2A9448E66394 CRC64; MDLKLLFISA LLGIISCSHA QQEGNECIKA NALSCGECIQ VGDKCGWCTD AEFLKQGEPT SARCDELESL KKRGCAEDKI ENPHGSQRIL KNTPVTNRKK GAEKLRPEDI TQIQPQKLSL QLRSGEPQNI KLKFKRAEDY PIDLYYLMDL SYSMKDDLEN VKNLGTSLMK EMSKITSDFR IGFGSFVEKT VMPYISTTPA KLLNPCTGDQ NCTSPFSYKN VLKLTSNGQR FNSLVGQQQI SGNLDSPEGG FDAIMQVAVC GEHIGWRNVT RLLVFSTDAG FHFAGDGKLG GIVLPNDGRC HLENDMYTMS HYYDYPSIAH LVQKLSENNI QTIFAVTEEF QPVYKELKNL IPKSAVGTLS ANSSNVINLI VDAYNSLSSE VILENSKLPE GVTITYQSRC KNGVVNEGES GRKCSNISIG DEVSFNINIT AQGCPKQGKT ETIKIKPLGF TEEVEITLSF ICECECHKHA MKNSPLCHNG NGSFECGACR CNKGRVGRQC ECRKDEVSTE DLDKNCRKDN GTDICSNNGE CVCGTCECKK RENPEERYSG KYCECDNFNC DRSNNKLCGG HGRCECRVCV CDANYTGSAC DCSLDTSTCL ASNKQICNGR GICECGTCRC TDPKFQGPTC EICPTCPGVC TEHKECVQCR AFGTGEKKDT CKRDCSYFNL IEVEDRDKLP QPVQAFPLMH CKERDARDCW FYYTYAVNNN TEKEVHVVKT MECPPGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN PIYKSAVTTV INPKYEGK //