ID F1QG85_DANRE Unreviewed; 798 AA.
AC F1QG85;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 16-MAR-2016, entry version 44.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=itgb1a {ECO:0000313|Ensembl:ENSDARP00000039699,
GN ECO:0000313|ZFIN:ZDB-GENE-060803-2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000039699, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000039699}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000039699};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000039699, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000039699,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the
RT human genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000633};
CC Single-pass type I membrane protein
CC {ECO:0000256|RuleBase:RU000633}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|RuleBase:RU000633}.
CC -!- SIMILARITY: Contains VWFA domain. {ECO:0000256|SAAS:SAAS00414638}.
CC -!- CAUTION: The sequence shown here is derived from an Ensembl
CC automatic analysis pipeline and should be considered as
CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000039699}.
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DR EMBL; BX322549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005170669.1; XM_005170612.2.
DR RefSeq; XP_009295475.1; XM_009297200.1.
DR RefSeq; XP_009295476.1; XM_009297201.1.
DR UniGene; Dr.134213; -.
DR STRING; 7955.ENSDARP00000039699; -.
DR Ensembl; ENSDART00000039700; ENSDARP00000039699; ENSDARG00000071863.
DR GeneID; 556734; -.
DR CTD; 556734; -.
DR ZFIN; ZDB-GENE-060803-2; itgb1a.
DR eggNOG; KOG1226; Eukaryota.
DR eggNOG; ENOG410XP60; LUCA.
DR GeneTree; ENSGT00760000119064; -.
DR OMA; LVGQQQI; -.
DR OrthoDB; EOG7T7GSB; -.
DR TreeFam; TF105392; -.
DR Reactome; R-DRE-1566948; Elastic fibre formation.
DR Reactome; R-DRE-1566977; Fibronectin matrix formation.
DR Reactome; R-DRE-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-DRE-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-DRE-210991; Basigin interactions.
DR Reactome; R-DRE-2129379; Molecules associated with elastic fibres.
DR Reactome; R-DRE-216083; Integrin cell surface interactions.
DR Reactome; R-DRE-3000157; Laminin interactions.
DR Reactome; R-DRE-3000178; ECM proteoglycans.
DR Reactome; R-DRE-445144; Signal transduction by L1.
DR Reactome; R-DRE-446343; Localization of the PINCH-ILK-PARVIN complex to focal adhesions.
DR Proteomes; UP000000437; Chromosome 24.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0001968; F:fibronectin binding; IGI:ZFIN.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:ZFIN.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.630; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR002369; Integrin_bsu_N.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR032695; Integrin_dom.
DR InterPro; IPR016201; Plexin-like_fold.
DR InterPro; IPR002035; VWF_A.
DR PANTHER; PTHR10082; PTHR10082; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF103575; SSF103575; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF69179; SSF69179; 1.
DR SUPFAM; SSF69687; SSF69687; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW Integrin {ECO:0000256|RuleBase:RU000633,
KW ECO:0000256|SAAS:SAAS00478940};
KW Membrane {ECO:0000256|SAAS:SAAS00478635};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|RuleBase:RU000633,
KW ECO:0000256|SAAS:SAAS00479639};
KW Transmembrane helix {ECO:0000256|SAAS:SAAS00478542}.
SQ SEQUENCE 798 AA; 88617 MW; E94A2A9448E66394 CRC64;
MDLKLLFISA LLGIISCSHA QQEGNECIKA NALSCGECIQ VGDKCGWCTD AEFLKQGEPT
SARCDELESL KKRGCAEDKI ENPHGSQRIL KNTPVTNRKK GAEKLRPEDI TQIQPQKLSL
QLRSGEPQNI KLKFKRAEDY PIDLYYLMDL SYSMKDDLEN VKNLGTSLMK EMSKITSDFR
IGFGSFVEKT VMPYISTTPA KLLNPCTGDQ NCTSPFSYKN VLKLTSNGQR FNSLVGQQQI
SGNLDSPEGG FDAIMQVAVC GEHIGWRNVT RLLVFSTDAG FHFAGDGKLG GIVLPNDGRC
HLENDMYTMS HYYDYPSIAH LVQKLSENNI QTIFAVTEEF QPVYKELKNL IPKSAVGTLS
ANSSNVINLI VDAYNSLSSE VILENSKLPE GVTITYQSRC KNGVVNEGES GRKCSNISIG
DEVSFNINIT AQGCPKQGKT ETIKIKPLGF TEEVEITLSF ICECECHKHA MKNSPLCHNG
NGSFECGACR CNKGRVGRQC ECRKDEVSTE DLDKNCRKDN GTDICSNNGE CVCGTCECKK
RENPEERYSG KYCECDNFNC DRSNNKLCGG HGRCECRVCV CDANYTGSAC DCSLDTSTCL
ASNKQICNGR GICECGTCRC TDPKFQGPTC EICPTCPGVC TEHKECVQCR AFGTGEKKDT
CKRDCSYFNL IEVEDRDKLP QPVQAFPLMH CKERDARDCW FYYTYAVNNN TEKEVHVVKT
MECPPGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTGEN
PIYKSAVTTV INPKYEGK
//