ID   F1NC33_CHICK            Unreviewed;       725 AA.
AC   F1NC33;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   31-JAN-2018, entry version 57.
DE   SubName: Full=Heat shock cognate protein HSP 90-beta {ECO:0000313|Ensembl:ENSGALP00000016523};
GN   Name=HSP90AB1 {ECO:0000313|Ensembl:ENSGALP00000016523};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000016523, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000016523, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000016523,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
RA   Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
RA   Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
RA   Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
RA   Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
RA   Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
RA   Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
RA   Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
RA   Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
RA   Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
RA   van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
RA   Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
RA   Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
RA   Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
RA   Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
RA   Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
RA   Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
RA   Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
RA   King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
RA   Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
RA   Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
RA   Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
RA   Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
RA   Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
RA   Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
RA   Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
RA   Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
RA   Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
RA   Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
RA   Mardis E.R., Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide
RT   unique perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000016523}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000016523};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGALP00000016523}.
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DR   EMBL; AADN04000139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015139110.1; XM_015283624.1.
DR   UniGene; Gga.4332; -.
DR   Ensembl; ENSGALT00000016542; ENSGALP00000016523; ENSGALG00000010175.
DR   GeneID; 396188; -.
DR   CTD; 3326; -.
DR   eggNOG; KOG0019; Eukaryota.
DR   eggNOG; KOG0020; Eukaryota.
DR   eggNOG; COG0326; LUCA.
DR   GeneTree; ENSGT00900000140936; -.
DR   OMA; LRYHSSQ; -.
DR   OrthoDB; EOG091G0270; -.
DR   Reactome; R-GGA-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-GGA-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR).
DR   Reactome; R-GGA-3371511; HSF1 activation.
DR   Reactome; R-GGA-3371568; Attenuation phase.
DR   Reactome; R-GGA-3371571; HSF1-dependent transactivation.
DR   Reactome; R-GGA-399954; Sema3A PAK dependent Axon repulsion.
DR   Reactome; R-GGA-6798695; Neutrophil degranulation.
DR   Reactome; R-GGA-844456; The NLRP3 inflammasome.
DR   Reactome; R-GGA-8937144; Aryl hydrocarbon receptor signalling.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000010175; -.
DR   GO; GO:0034751; C:aryl hydrocarbon receptor complex; IEA:Ensembl.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR   GO; GO:0043008; F:ATP-dependent protein binding; IEA:Ensembl.
DR   GO; GO:0045296; F:cadherin binding; IEA:Ensembl.
DR   GO; GO:0097718; F:disordered domain specific binding; IEA:Ensembl.
DR   GO; GO:0070182; F:DNA polymerase binding; IEA:Ensembl.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
DR   GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR   GO; GO:1990226; F:histone methyltransferase binding; IEA:Ensembl.
DR   GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR   GO; GO:0023026; F:MHC class II protein complex binding; IEA:Ensembl.
DR   GO; GO:0042277; F:peptide binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0019887; F:protein kinase regulator activity; IEA:Ensembl.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl.
DR   GO; GO:0051131; P:chaperone-mediated protein complex assembly; IEA:Ensembl.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0071157; P:negative regulation of cell cycle arrest; IEA:Ensembl.
DR   GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:1901389; P:negative regulation of transforming growth factor beta activation; IEA:Ensembl.
DR   GO; GO:0045597; P:positive regulation of cell differentiation; IEA:Ensembl.
DR   GO; GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IEA:Ensembl.
DR   GO; GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Ensembl.
DR   GO; GO:0051973; P:positive regulation of telomerase activity; IEA:Ensembl.
DR   GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0031396; P:regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0060338; P:regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0006950; P:response to stress; IEA:InterPro.
DR   GO; GO:0097435; P:supramolecular fiber organization; IEA:Ensembl.
DR   GO; GO:1905323; P:telomerase holoenzyme complex assembly; IEA:Ensembl.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; IEA:Ensembl.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:Ensembl.
DR   CDD; cd00075; HATPase_c; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00505; HSP90; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR019805; Heat_shock_protein_90_CS.
DR   InterPro; IPR037196; HSP90_C.
DR   InterPro; IPR001404; Hsp90_fam.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   PANTHER; PTHR11528; PTHR11528; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00183; HSP90; 1.
DR   PIRSF; PIRSF002583; Hsp90; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF110942; SSF110942; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS00298; HSP90; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000539};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT   DOMAIN       35    189       HATPase_c. {ECO:0000259|SMART:SM00387}.
FT   COILED      216    247       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   725 AA;  83488 MW;  504BC0981E3EDAF2 CRC64;
     MPEQVQHGED EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT
     DPSKLDTGKD LKIDIVPNPR DRTLTLLDTG IGMTKADLVN NLGTIAKSGT KAFMEALQAG
     ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRTD HGEPIGRGTK
     VILYLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYVEKE REKEISDDEA EEEKAEKEEE
     ESKDEEKPKI EDVGSDEEEE EGEKSKKKKT KKIKEKYIDQ EELNKTKPIW TRNPDDITQE
     EYGEFYKSLT NDWEDHLAVK HFSVEGQLEF RALLFIPRRA PFDLFENKKK KNNIKLYVRR
     VFIMDSCDEL IPEYLNFIRG VVDSEDLPLN ISREMLQQSK ILKVIRKNIV KKCLELFTEL
     AEDKENYKKF YEAFSKNLKL GIHEDSTNRK RLSELLRYHT SQSGDEMTSL SEYVSRMKES
     QKSIYYITGE SKEQVANSAF VERVRKRGFE VVYMTEPIDE YCVQQLKEFD GKTLVSVTKE
     GLELPEDEEE KKKMEESKAK FETLCKLMKE ILDKKVEKVT ISNRLVSSPC CIVTSTYGWT
     ANMERIMKAQ ALRDNSTMGY MMAKKHLEIN PDHPIVETLR QKADADKNDK AVKDLVVLLF
     ETALLSSGFS LEDPQTHSNR IYRMIKLGLG IDEDEVIAEE SSIAPPDEIP PLEGDEDTSR
     MEEVD
//