ID F1MUZ9_BOVIN Unreviewed; 573 AA. AC F1MUZ9; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 02-JUN-2021, entry version 80. DE RecName: Full=60 kDa chaperonin {ECO:0000256|ARBA:ARBA00020642}; DE EC=5.6.1.7 {ECO:0000256|ARBA:ARBA00012198}; DE AltName: Full=60 kDa heat shock protein, mitochondrial {ECO:0000256|ARBA:ARBA00019981}; DE AltName: Full=Chaperonin 60 {ECO:0000256|ARBA:ARBA00017705}; DE AltName: Full=Heat shock protein 60 {ECO:0000256|ARBA:ARBA00021626}; GN Name=HSPD1 {ECO:0000313|Ensembl:ENSBTAP00000016708, GN ECO:0000313|VGNC:VGNC:49070}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000016708, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000016708} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016708}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000016708, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016708, RC ECO:0000313|Proteomes:UP000009136}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H(2)O + a folded polypeptide = ADP + phosphate + an CC unfolded polypeptide.; EC=5.6.1.7; CC Evidence={ECO:0000256|ARBA:ARBA00000078}; CC -!- SIMILARITY: Belongs to the chaperonin (HSP60) family. CC {ECO:0000256|ARBA:ARBA00006607, ECO:0000256|RuleBase:RU000418}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001160080.1; NM_001166608.1. DR RefSeq; NP_001160081.1; NM_001166609.1. DR RefSeq; NP_001160082.1; NM_001166610.1. DR SMR; F1MUZ9; -. DR PRIDE; F1MUZ9; -. DR Ensembl; ENSBTAT00000016708; ENSBTAP00000016708; ENSBTAG00000012586. DR Ensembl; ENSBTAT00000064253; ENSBTAP00000055431; ENSBTAG00000012586. DR GeneID; 511913; -. DR KEGG; bta:511913; -. DR CTD; 3329; -. DR VGNC; VGNC:49070; HSPD1. DR GeneTree; ENSGT00390000005727; -. DR HOGENOM; CLU_016503_3_0_1; -. DR OMA; TDTDKME; -. DR OrthoDB; 415781at2759; -. DR TreeFam; TF300475; -. DR Proteomes; UP000009136; Chromosome 2. DR Bgee; ENSBTAG00000012586; Expressed in adrenal gland and 97 other tissues. DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central. DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016887; F:ATPase activity; IEA:InterPro. DR GO; GO:0051087; F:chaperone binding; IBA:GO_Central. DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW. DR GO; GO:0008637; P:apoptotic mitochondrial changes; IBA:GO_Central. DR GO; GO:0034514; P:mitochondrial unfolded protein response; IBA:GO_Central. DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IBA:GO_Central. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IBA:GO_Central. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IBA:GO_Central. DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central. DR GO; GO:0006457; P:protein folding; IBA:GO_Central. DR GO; GO:0045041; P:protein import into mitochondrial intermembrane space; IBA:GO_Central. DR GO; GO:0042026; P:protein refolding; IEA:InterPro. DR GO; GO:0009409; P:response to cold; ISS:AgBase. DR GO; GO:0042110; P:T cell activation; IBA:GO_Central. DR CDD; cd03344; GroEL; 1. DR Gene3D; 1.10.560.10; -; 1. DR Gene3D; 3.30.260.10; -; 1. DR Gene3D; 3.50.7.10; -; 1. DR HAMAP; MF_00600; CH60; 1. DR InterPro; IPR018370; Chaperonin_Cpn60_CS. DR InterPro; IPR001844; Chaprnin_Cpn60. DR InterPro; IPR002423; Cpn60/TCP-1. DR InterPro; IPR027409; GroEL-like_apical_dom_sf. DR InterPro; IPR027413; GROEL-like_equatorial_sf. DR InterPro; IPR027410; TCP-1-like_intermed_sf. DR Pfam; PF00118; Cpn60_TCP1; 1. DR PRINTS; PR00298; CHAPERONIN60. DR SUPFAM; SSF48592; SSF48592; 1. DR SUPFAM; SSF52029; SSF52029; 1. DR SUPFAM; SSF54849; SSF54849; 1. DR TIGRFAMs; TIGR02348; GroEL; 1. DR PROSITE; PS00296; CHAPERONINS_CPN60; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Chaperone {ECO:0000256|ARBA:ARBA00023186}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Isomerase {ECO:0000256|ARBA:ARBA00023235}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Proteomics identification {ECO:0007829|PeptideAtlas:F1MUZ9}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT COILED 364..384 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 573 AA; 60978 MW; A89C00A4C74010AE CRC64; MLRLPAVLRQ MRPVSRALAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK EIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ DAYVLLSEKK ISSVQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL NLNLEDVQPH DLGKVGEVIV TKDDAMLLKG KGDKAQIEKR IQEIIEQLDI TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR VTDALNATRA AVEEGIVLGG GCALLRCIPA LESITPANED QKTGIEIIKK TLKIPAMTIA KNAGVEGSLI VEKIMQSSSE VGYDAMLGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT TAEVVVTEIP KEEKDPGMGG MGGMGGGMGG GMF //