ID F1MUZ9_BOVIN Unreviewed; 573 AA. AC F1MUZ9; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 10-APR-2019, entry version 67. DE SubName: Full=60 kDa heat shock protein, mitochondrial {ECO:0000313|Ensembl:ENSBTAP00000016708}; GN Name=HSPD1 {ECO:0000313|Ensembl:ENSBTAP00000016708, GN ECO:0000313|VGNC:VGNC:49070}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000016708, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000016708, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016708, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000016708} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016708}; RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the chaperonin (HSP60) family. CC {ECO:0000256|RuleBase:RU000418}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001160080.1; NM_001166608.1. DR RefSeq; NP_001160081.1; NM_001166609.1. DR RefSeq; NP_001160082.1; NM_001166610.1. DR UniGene; Bt.24270; -. DR Ensembl; ENSBTAT00000016708; ENSBTAP00000016708; ENSBTAG00000012586. DR Ensembl; ENSBTAT00000064253; ENSBTAP00000055431; ENSBTAG00000012586. DR GeneID; 511913; -. DR KEGG; bta:511913; -. DR CTD; 3329; -. DR VGNC; VGNC:49070; HSPD1. DR eggNOG; KOG0356; Eukaryota. DR eggNOG; COG0459; LUCA. DR GeneTree; ENSGT00390000005727; -. DR KO; K04077; -. DR OMA; TDTDKME; -. DR OrthoDB; 415781at2759; -. DR TreeFam; TF300475; -. DR Proteomes; UP000009136; Chromosome 2. DR Bgee; ENSBTAG00000012586; Expressed in 10 organ(s), highest expression level in adult mammalian kidney. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central. DR GO; GO:0006458; P:'de novo' protein folding; IBA:GO_Central. DR GO; GO:0008637; P:apoptotic mitochondrial changes; IBA:GO_Central. DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central. DR GO; GO:0045041; P:protein import into mitochondrial intermembrane space; IBA:GO_Central. DR GO; GO:0042026; P:protein refolding; IEA:InterPro. DR GO; GO:0009409; P:response to cold; ISS:AgBase. DR GO; GO:0042110; P:T cell activation; IBA:GO_Central. DR CDD; cd03344; GroEL; 1. DR Gene3D; 1.10.560.10; -; 1. DR Gene3D; 3.30.260.10; -; 1. DR Gene3D; 3.50.7.10; -; 1. DR HAMAP; MF_00600; CH60; 1. DR InterPro; IPR018370; Chaperonin_Cpn60_CS. DR InterPro; IPR001844; Chaprnin_Cpn60. DR InterPro; IPR002423; Cpn60/TCP-1. DR InterPro; IPR027409; GroEL-like_apical_dom_sf. DR InterPro; IPR027413; GROEL-like_equatorial_sf. DR InterPro; IPR027410; TCP-1-like_intermed_sf. DR Pfam; PF00118; Cpn60_TCP1; 1. DR PRINTS; PR00298; CHAPERONIN60. DR SUPFAM; SSF48592; SSF48592; 1. DR SUPFAM; SSF52029; SSF52029; 1. DR SUPFAM; SSF54849; SSF54849; 1. DR TIGRFAMs; TIGR02348; GroEL; 1. DR PROSITE; PS00296; CHAPERONINS_CPN60; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Proteomics identification {ECO:0000213|PeptideAtlas:F1MUZ9}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT COILED 364 384 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 573 AA; 60978 MW; A89C00A4C74010AE CRC64; MLRLPAVLRQ MRPVSRALAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK EIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ DAYVLLSEKK ISSVQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL NLNLEDVQPH DLGKVGEVIV TKDDAMLLKG KGDKAQIEKR IQEIIEQLDI TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR VTDALNATRA AVEEGIVLGG GCALLRCIPA LESITPANED QKTGIEIIKK TLKIPAMTIA KNAGVEGSLI VEKIMQSSSE VGYDAMLGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT TAEVVVTEIP KEEKDPGMGG MGGMGGGMGG GMF //