ID F1MUZ9_BOVIN Unreviewed; 573 AA. AC F1MUZ9; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 29-OCT-2014, entry version 30. DE SubName: Full=60 kDa heat shock protein, mitochondrial {ECO:0000313|Ensembl:ENSBTAP00000016708}; GN Name=HSPD1 {ECO:0000313|Ensembl:ENSBTAP00000016708}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; OC Pecora; Bovidae; Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000016708, ECO:0000313|Proteomes:UP000009136}; RN [1] {ECO:0000313|Ensembl:ENSBTAP00000016708, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016708, RC ECO:0000313|Proteomes:UP000009136}; RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42; RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., RA Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., RA Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.; RT "A whole-genome assembly of the domestic cow, Bos taurus."; RL Genome Biol. 10:R42.01-R42.10(2009). RN [2] {ECO:0000313|Ensembl:ENSBTAP00000016708} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000016708}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSBTAP00000055431} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055431}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the chaperonin (HSP60) family. CC {ECO:0000256|RuleBase:RU000418}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSBTAP00000016708}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DAAA02005515; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001160080.1; NM_001166608.1. DR RefSeq; NP_001160081.1; NM_001166609.1. DR RefSeq; NP_001160082.1; NM_001166610.1. DR UniGene; Bt.24270; -. DR Ensembl; ENSBTAT00000016708; ENSBTAP00000016708; ENSBTAG00000012586. DR Ensembl; ENSBTAT00000064253; ENSBTAP00000055431; ENSBTAG00000012586. DR GeneID; 511913; -. DR KEGG; bta:511913; -. DR CTD; 3329; -. DR GeneTree; ENSGT00390000005727; -. DR KO; K04077; -. DR OMA; NYKAANE; -. DR OrthoDB; EOG7HTHGJ; -. DR TreeFam; TF300475; -. DR Reactome; REACT_215731; Mitochondrial protein import. DR NextBio; 20870158; -. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005905; C:coated pit; IEA:Ensembl. DR GO; GO:0030135; C:coated vesicle; IEA:Ensembl. DR GO; GO:0019907; C:cyclin-dependent protein kinase activating kinase holoenzyme complex; IEA:Ensembl. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005769; C:early endosome; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl. DR GO; GO:0046696; C:lipopolysaccharide receptor complex; IEA:Ensembl. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0030141; C:secretory granule; IEA:Ensembl. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl. DR GO; GO:0044822; F:poly(A) RNA binding; IEA:Ensembl. DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl. DR GO; GO:0002368; P:B cell cytokine production; IEA:Ensembl. DR GO; GO:0042100; P:B cell proliferation; IEA:Ensembl. DR GO; GO:0048291; P:isotype switching to IgG isotypes; IEA:Ensembl. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl. DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl. DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl. DR GO; GO:0050870; P:positive regulation of T cell activation; IEA:Ensembl. DR GO; GO:0002842; P:positive regulation of T cell mediated immune response to tumor cell; IEA:Ensembl. DR GO; GO:0042026; P:protein refolding; IEA:Ensembl. DR GO; GO:0006986; P:response to unfolded protein; IEA:Ensembl. DR GO; GO:0042110; P:T cell activation; IEA:Ensembl. DR Gene3D; 1.10.560.10; -; 2. DR Gene3D; 3.50.7.10; -; 1. DR HAMAP; MF_00600; CH60; 1. DR InterPro; IPR018370; Chaperonin_Cpn60_CS. DR InterPro; IPR001844; Chaprnin_Cpn60. DR InterPro; IPR002423; Cpn60/TCP-1. DR InterPro; IPR027409; GroEL-like_apical_dom. DR InterPro; IPR027413; GROEL-like_equatorial. DR PANTHER; PTHR11353; PTHR11353; 1. DR Pfam; PF00118; Cpn60_TCP1; 1. DR PRINTS; PR00298; CHAPERONIN60. DR SUPFAM; SSF48592; SSF48592; 2. DR SUPFAM; SSF52029; SSF52029; 1. DR TIGRFAMs; TIGR02348; GroEL; 1. DR PROSITE; PS00296; CHAPERONINS_CPN60; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|RuleBase:RU003319}; KW Chaperone {ECO:0000256|RuleBase:RU003319}; KW Complete proteome {ECO:0000313|Proteomes:UP000009136}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU003319}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. SQ SEQUENCE 573 AA; 60978 MW; A89C00A4C74010AE CRC64; MLRLPAVLRQ MRPVSRALAP HLTRAYAKDV KFGADARALM LQGVDLLADA VAVTMGPKGR TVIIEQSWGS PKVTKDGVTV AKSIDLKDKY KNIGAKLVQD VANNTNEEAG DGTTTATVLA RSIAKEGFEK ISKGANPVEI RRGVMLAVDA VIAELKKQSK PVTTPEEIAQ VATISANGDK EIGNIISDAM KKVGRKGVIT VKDGKTLNDE LEIIEGMKFD RGYISPYFIN TSKGQKCEFQ DAYVLLSEKK ISSVQSIVPA LEIANAHRKP LVIIAEDVDG EALSTLVLNR LKVGLQVVAV KAPGFGDNRK NQLKDMAIAT GGAVFGEEGL NLNLEDVQPH DLGKVGEVIV TKDDAMLLKG KGDKAQIEKR IQEIIEQLDI TTSEYEKEKL NERLAKLSDG VAVLKVGGTS DVEVNEKKDR VTDALNATRA AVEEGIVLGG GCALLRCIPA LESITPANED QKTGIEIIKK TLKIPAMTIA KNAGVEGSLI VEKIMQSSSE VGYDAMLGDF VNMVEKGIID PTKVVRTALL DAAGVASLLT TAEVVVTEIP KEEKDPGMGG MGGMGGGMGG GMF //