ID F1LP59_RAT Unreviewed; 988 AA. AC F1LP59; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 25-MAY-2022, sequence version 4. DT 03-AUG-2022, entry version 68. DE RecName: Full=Rab3 GTPase-activating protein catalytic subunit {ECO:0000256|ARBA:ARBA00015817}; GN Name=Rab3gap1 {ECO:0000313|Ensembl:ENSRNOP00000005289, GN ECO:0000313|RGD:1306487}; GN Synonyms=RGD1306487 {ECO:0000313|RGD:1306487}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000005289, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000005289, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000005289, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000005289} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000005289}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC -!- SIMILARITY: Belongs to the Rab3-GAP catalytic subunit family. CC {ECO:0000256|ARBA:ARBA00008856}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR IntAct; F1LP59; 1. DR jPOST; F1LP59; -. DR PeptideAtlas; F1LP59; -. DR PRIDE; F1LP59; -. DR Ensembl; ENSRNOT00000005289.8; ENSRNOP00000005289.8; ENSRNOG00000003953.8. DR RGD; 1306487; Rab3gap1. DR VEuPathDB; HostDB:ENSRNOG00000003953; -. DR GeneTree; ENSGT00390000006705; -. DR HOGENOM; CLU_012561_1_0_1; -. DR TreeFam; TF314500; -. DR Proteomes; UP000002494; Chromosome 13. DR Bgee; ENSRNOG00000003953; Expressed in frontal cortex and 18 other tissues. DR ExpressionAtlas; F1LP59; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. DR GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro. DR InterPro; IPR045700; Rab3GAP1. DR InterPro; IPR045698; Rab3GAP1_C. DR InterPro; IPR026147; Rab3GAP1_conserved. DR PANTHER; PTHR21422; PTHR21422; 1. DR Pfam; PF19533; Rab3-GAP_cat_C; 1. DR Pfam; PF13890; Rab3-GTPase_cat; 1. PE 1: Evidence at protein level; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}; KW Proteomics identification {ECO:0007829|PeptideAtlas:F1LP59}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 615..768 FT /note="Rab3-GTPase_cat" FT /evidence="ECO:0000259|Pfam:PF13890" FT DOMAIN 780..988 FT /note="Rab3-GAP_cat_C" FT /evidence="ECO:0000259|Pfam:PF19533" FT REGION 530..557 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 592..620 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 988 AA; 110964 MW; DC506627B3A85408 CRC64; MAADSEPESE VFEITDFTTA SEWERFISKV EEVLNDWKLI GHSLGKPLEK GIFTSGTWEE RADEISFADF RFSVTHHYLV QESPDKEGKD EESEDAIPQS MQDLLCMNND FPPRAHCLVR WYGLREFVVI APAAHSDAVL SESKCNLLLS SISIALGNTG CQVPLFVQIH HKWRRMYMGE CQGPGVRTDF EMVHLRKVPN QYTHLSGLLD IFKSKIGCPL TPLPPVSIAI RFTYVLQDWQ QYFWPQQPPD IDALVGGEVG GLEFGKLPFG ACEDPISELH LATTWPHLTE GIIVDNDVYS DLDPVQAPHW SVRVRKADNP QCLLGDFVTE FLKICRRKES TDEILGRSTF EEEGRDVADI THALSKLTEP APVPIHKLSV SNMVHTAKKK IRKHRGEESP LNNDVLNTIL LFLFPDAASE KPLDGTTSVD NSNPTAEAGD YTLYNQFKSA PSDSLTYKLA LCLCMINFYH GGLKGVAHLW QEFVLEMRFR WENNFLIPGL ASGPPDLRCC LLHQKLQMLN CCIERKKARD EGKKTSPSDS MTKAYPADAG KAGGQLGLDH LRDTEKEKGE AGKSWDSWSD SEEEFFECLS DAEDLRGNGQ ESTKKGGPKD MAPLKPEGRL HQHGKLTLLR NGEPLYIPVT QEPAPMTEDL LEEQSEVLAK LGTSAEGAHL RARMQSACLL SDMESFKAAN PGCCLEDFVR WYSPRDYIEE EVTDEKGNVV LKGELSARMK IPSNMWVEAW ETAKPVPARR QRRLFDDTRE AEKVLHYLAM QKPADLARHL LPCVIHAAVL KVKEEESLEN IPSVKKIIKQ IIAHSSKVLR FPSPEDKKLE EIILQITTVE AIIARARSLK AKFGTEKCEH EEEKEDLERF VSCLLEQPEV AVTGAGRGHA GRIIHKLFVN AQRLTESSDE AAAVALPEEE LKRSGCPEER RQTLVSDFPP PAGRELILRA TVPRPAPYSK ALPQRMYSVL TKEDFRLAGA FSSDTSFF //