ID F1LP59_RAT Unreviewed; 767 AA. AC F1LP59; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 3. DT 19-JAN-2022, entry version 66. DE RecName: Full=Rab3 GTPase-activating protein catalytic subunit {ECO:0000256|ARBA:ARBA00015817}; GN Name=Rab3gap1 {ECO:0000313|Ensembl:ENSRNOP00000005289, GN ECO:0000313|RGD:1306487}; GN Synonyms=RGD1306487 {ECO:0000313|RGD:1306487}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000005289, ECO:0000313|Proteomes:UP000002494}; RN [1] {ECO:0000313|Ensembl:ENSRNOP00000005289, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000005289, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [2] {ECO:0000313|Ensembl:ENSRNOP00000005289} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000005289}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC -!- SIMILARITY: Belongs to the Rab3-GAP catalytic subunit family. CC {ECO:0000256|ARBA:ARBA00008856}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AABR07020883; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR IntAct; F1LP59; 1. DR jPOST; F1LP59; -. DR PeptideAtlas; F1LP59; -. DR Ensembl; ENSRNOT00000005289; ENSRNOP00000005289; ENSRNOG00000003953. DR RGD; 1306487; Rab3gap1. DR GeneTree; ENSGT00390000006705; -. DR HOGENOM; CLU_012561_1_0_1; -. DR OMA; QIRTDAF; -. DR TreeFam; TF314500; -. DR Proteomes; UP000002494; Chromosome 13. DR Bgee; ENSRNOG00000003953; Expressed in brain and 20 other tissues. DR ExpressionAtlas; F1LP59; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro. DR InterPro; IPR045700; Rab3GAP1. DR InterPro; IPR045698; Rab3GAP1_C. DR InterPro; IPR026147; Rab3GAP1_conserved. DR PANTHER; PTHR21422; PTHR21422; 1. DR Pfam; PF19533; Rab3-GAP_cat_C; 1. DR Pfam; PF13890; Rab3-GTPase_cat; 1. PE 1: Evidence at protein level; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}; KW Proteomics identification {ECO:0007829|PeptideAtlas:F1LP59}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}. FT DOMAIN 399..552 FT /note="Rab3-GTPase_cat" FT /evidence="ECO:0000259|Pfam:PF13890" FT DOMAIN 564..767 FT /note="Rab3-GAP_cat_C" FT /evidence="ECO:0000259|Pfam:PF19533" FT REGION 315..341 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 376..404 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 767 AA; 85881 MW; 53CF505AE3E36E27 CRC64; GCPLTPLPPV SIAIRFTYVL QDWQQYFWPQ QPPDIDALVG GEVGGLEFGK LPFGACEDPI SELHLATTWP HLTEGIIVDN DVYSDLDPVQ APHWSVRVRK ADNPQCLLGD FVTEFLKICR RKESTDEILG RSTFEEEGRD VADITHALSK LTEPAPVPIH KLSVSNMVHT AKKKIRKHRG EESPLNNDVL NTILLGLFPT IMPVKKLSQK LSIISCSPTA EAGDYTLYNQ FKSAPSDSLT YKLALCLCMI NFYHGGLKGV AHLWQEFVLE MRFRWENNFL IPGLASGPPD LRCCLLHQKL QMLNCCIERK KARDEGKKTS PSDSMTKAYP ADAGKAGGQL GLDHLRDTEK EKGEAGKSWD SWSDSEEEFF ECLSDAEDLR GNGQESTKKG GPKDMAPLKP EGRLHQHGKL TLLRNGEPLY IPVTQEPAPM TEDLLEEQSE VLAKLGTSAE GAHLRARMQS ACLLSDMESF KAANPGCCLE DFVRWYSPRD YIEEEVTDEK GNVVLKGELS ARMKIPSNMW VEAWETAKPV PARRQRRLFD DTREAEKVLH YLAMQKPADL ARHLLPCVIH AAVLKVKEEE TESLENIPSV KKIIKQIIAH SSKVLRFPSP EDKKLEEIIL QITTVEAIIA RARSLKAKFG TEKCEHEEEK EDLERFVSCL LEQPEVAVTG AGRGHAGRII HKLFVNAQRA AAVALPEEEL KRSGCPEERR QTLVSDFPPP AGRELILRAT VPRPAPYSKA LPQRMYSVLT KEDFRLAGAF SSDTSFF //