ID F1CME7_HUMAN Unreviewed; 359 AA. AC F1CME7; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 24-JAN-2024, entry version 40. DE SubName: Full=Hepatitis A virus cellular receptor 1b {ECO:0000313|EMBL:ADZ24773.1}; GN Name=HAVCR1 {ECO:0000313|EMBL:ADZ24773.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ADZ24773.1}; RN [1] {ECO:0000313|EMBL:ADZ24773.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21412435; DOI=10.1371/journal.pone.0017787; RA Ivie S.E., Shang J., Rubin D.H., McClain M.S.; RT "Gene-trap mutagenesis identifies mammalian genes contributing to RT intoxication by Clostridium perfringens ?-toxin."; RL PLoS ONE 6:e17787-e17787(2011). CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane CC protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. TIM family. CC {ECO:0000256|ARBA:ARBA00038203}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ412640; ADZ24773.1; -; mRNA. DR AlphaFoldDB; F1CME7; -. DR PeptideAtlas; F1CME7; -. DR ChiTaRS; HAVCR1; human. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR PANTHER; PTHR47009:SF1; HEPATITIS A VIRUS CELLULAR RECEPTOR 1; 1. DR PANTHER; PTHR47009; HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG; 1. DR Pfam; PF07686; V-set; 1. DR SMART; SM00409; IG; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000313|EMBL:ADZ24773.1}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..359 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003266390" FT TRANSMEM 291..311 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 3..121 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT REGION 211..257 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 218..257 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 359 AA; 38674 MW; F5DC8ED8D40EF540 CRC64; MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG SCSLFTCQNG IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPTTT VPTTMSIPTT TTVPTTMTVS TTTSVPTTTS IPTTTSVPVT TAVSTFVPPM PLPRQNHEPV ATSPSSPQPA ETHPTTLQGA IRREPTSSPL YSYTTDGNDT VTESSDGLWN NNQTQLFLEH SLLTANTTKG IYAGVCISVL VLLALLGVII AKKYFFKKEV QQLSVSFSSL QIKALQNAVE KEVQAEDNIY IENSLYATD //