ID F0I6Z6_STRSA Unreviewed; 108 AA. AC F0I6Z6; DT 03-MAY-2011, integrated into UniProtKB/TrEMBL. DT 03-MAY-2011, sequence version 1. DT 08-MAY-2019, entry version 28. DE RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN Name=crcB1 {ECO:0000313|EMBL:EGD31626.1}; GN Synonyms=crcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN ORFNames=HMPREF9382_0579 {ECO:0000313|EMBL:EGD31626.1}; OS Streptococcus sanguinis SK115. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=888810 {ECO:0000313|EMBL:EGD31626.1, ECO:0000313|Proteomes:UP000003351}; RN [1] {ECO:0000313|EMBL:EGD31626.1, ECO:0000313|Proteomes:UP000003351} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SK115 {ECO:0000313|EMBL:EGD31626.1, RC ECO:0000313|Proteomes:UP000003351}; RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., RA Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., RA Korchina V., Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., RA Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., RA Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., RA San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., RA Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., RA Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., RA Petrosino J., Highlander S., Gibbs R.; RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Important for reducing fluoride concentration in the CC cell, thus reducing its toxicity. {ECO:0000256|HAMAP- CC Rule:MF_00454, ECO:0000256|SAAS:SAAS00388086}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP- CC Rule:MF_00454}; Multi-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_00454}. CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. CC {ECO:0000256|HAMAP-Rule:MF_00454, ECO:0000256|SAAS:SAAS00573618}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:EGD31626.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AEXW01000005; EGD31626.1; -; Genomic_DNA. DR EnsemblBacteria; EGD31626; EGD31626; HMPREF9382_0579. DR PATRIC; fig|888810.3.peg.561; -. DR Proteomes; UP000003351; Unassembled WGS sequence. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0015103; F:inorganic anion transmembrane transporter activity; IEA:UniProtKB-UniRule. DR HAMAP; MF_00454; CrcB; 1. DR InterPro; IPR003691; CrcB. DR PANTHER; PTHR28259; PTHR28259; 1. DR Pfam; PF02537; CRCB; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702610}; KW Complete proteome {ECO:0000313|Proteomes:UP000003351}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702614}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702612}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702611}; KW Transport {ECO:0000256|HAMAP-Rule:MF_00454, KW ECO:0000256|SAAS:SAAS00702613}. FT TRANSMEM 30 48 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. FT TRANSMEM 55 75 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. FT TRANSMEM 87 107 Helical. {ECO:0000256|HAMAP-Rule: FT MF_00454}. SQ SEQUENCE 108 AA; 11967 MW; 3CA2DE9B0C0790E3 CRC64; MMWAILICCG AGSLVRYVFS KVNSRAYLPI GTLLANLLGA FLIGYFYNHI EDKQLYVILA TGFCGGLTTF STLNAELAAL FPERKKFLLY LALTYILGFL AILLGIFI //