ID E9QH31_DANRE Unreviewed; 490 AA. AC E9QH31; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 2. DT 14-OCT-2015, entry version 32. DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492}; GN Name=aldh3a2b {ECO:0000313|Ensembl:ENSDARP00000103212, GN ECO:0000313|ZFIN:ZDB-GENE-040912-103}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000103212, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000103212} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000103212}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [2] {ECO:0000313|Ensembl:ENSDARP00000103212, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000103212, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. CC {ECO:0000256|PIRNR:PIRNR036492}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000103212}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU463284; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9QH31; -. DR STRING; 7955.ENSDARP00000103212; -. DR Ensembl; ENSDART00000114885; ENSDARP00000103212; ENSDARG00000029381. DR ZFIN; ZDB-GENE-040912-103; aldh3a2b. DR GeneTree; ENSGT00390000002825; -. DR InParanoid; E9QH31; -. DR OMA; PDAKVMQ; -. DR OrthoDB; EOG73RBB3; -. DR TreeFam; TF314264; -. DR Proteomes; UP000000437; Chromosome 21. DR Bgee; E9QH31; -. DR GO; GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; IBA:GO_Central. DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IBA:GO_Central. DR GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro. DR GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro. DR Gene3D; 3.40.309.10; -; 1. DR Gene3D; 3.40.605.10; -; 1. DR InterPro; IPR016161; Ald_DH/histidinol_DH. DR InterPro; IPR016163; Ald_DH_C. DR InterPro; IPR016160; Ald_DH_CS_CYS. DR InterPro; IPR029510; Ald_DH_CS_GLU. DR InterPro; IPR016162; Ald_DH_N. DR InterPro; IPR015590; Aldehyde_DH_dom. DR InterPro; IPR012394; Aldehyde_DH_NAD(P). DR Pfam; PF00171; Aldedh; 1. DR PIRSF; PIRSF036492; ALDH; 1. DR SUPFAM; SSF53720; SSF53720; 1. DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1. DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR036492}; KW Proteomics identification {ECO:0000213|PeptideAtlas:E9QH31}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 470 488 Helical. {ECO:0000256|SAM:Phobius}. FT COILED 30 50 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 490 AA; 55060 MW; 081558B1890338EF CRC64; MSREQKAVER ARKAFFTGRS KSLEYRISQL KNLQRFMQER QKEIAEALKK DLKRSEFGTS LYETLGVESE INLALKKLKE WAAPRPVNKS LMTISDQVYI QPEPLGVVLI IGAWNYPWAV TVGPLVGAIA AGNAAVIKPS EVSAHTSKVM EEFLPLYLDK ELYPVVTGGV KETQELLKQR FDHIFYTGNG MVGKIIMEAA AKHLTPTTLE LGGKSPCYID KDCDLTIACR RIAWGKYSNC GQTCIAPDYI LCDPSIQDRV IEEIKKNIKE FYTENPQKCP DYGRIINQRH FKRLMSLMEG SSIAVSGEHN EAECYIAPTV LRDVKPDAKV MQEEIFGPLL PIVTVNSVDE AIKFINQRDK PLALYIFSSD KKLIDRMIAE TSSGGLMAND CLMHFSVSSL PFGGVGDSGM GRYHGKHGFD NLSHMRGVLL KQLKMEAVNK MRYPPHTADK LGWARFFIVR HVDFGSLGRM AMLALMVVFA AVIIQKYFTD //