ID E9Q9A6_MOUSE Unreviewed; 308 AA. AC E9Q9A6; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 02-OCT-2024, entry version 82. DE SubName: Full=Interleukin 20 receptor beta {ECO:0000313|Ensembl:ENSMUSP00000096057.4}; GN Name=Il20rb {ECO:0000313|Ensembl:ENSMUSP00000096057.4, GN ECO:0000313|MGI:MGI:2143266}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000096057.4, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000096057.4, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000096057.4, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000096057.4} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000096057.4}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000096057.4} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000096057.4}; RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001028715.2; NM_001033543.3. DR AlphaFoldDB; E9Q9A6; -. DR SMR; E9Q9A6; -. DR STRING; 10090.ENSMUSP00000096057; -. DR PhosphoSitePlus; E9Q9A6; -. DR PaxDb; 10090-ENSMUSP00000096057; -. DR Antibodypedia; 17858; 297 antibodies from 28 providers. DR Ensembl; ENSMUST00000098458.4; ENSMUSP00000096057.4; ENSMUSG00000044244.19. DR GeneID; 213208; -. DR KEGG; mmu:213208; -. DR UCSC; uc009rev.2; mouse. DR AGR; MGI:2143266; -. DR CTD; 53833; -. DR MGI; MGI:2143266; Il20rb. DR VEuPathDB; HostDB:ENSMUSG00000044244; -. DR eggNOG; ENOG502S2V6; Eukaryota. DR GeneTree; ENSGT00510000048354; -. DR HOGENOM; CLU_074126_1_0_1; -. DR InParanoid; E9Q9A6; -. DR OMA; QGEYERY; -. DR OrthoDB; 5354301at2759; -. DR PhylomeDB; E9Q9A6; -. DR TreeFam; TF332537; -. DR Reactome; R-MMU-8854691; Interleukin-20 family signaling. DR BioGRID-ORCS; 213208; 0 hits in 76 CRISPR screens. DR Proteomes; UP000000589; Chromosome 9. DR RNAct; E9Q9A6; protein. DR Bgee; ENSMUSG00000044244; Expressed in lip and 71 other cell types or tissues. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central. DR GO; GO:0042015; F:interleukin-20 binding; IPI:MGI. DR GO; GO:0160165; P:CD8-positive, alpha-beta T cell homeostasis; IMP:MGI. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI. DR GO; GO:0002765; P:immune response-inhibiting signal transduction; IMP:MGI. DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IMP:MGI. DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IMP:MGI. DR GO; GO:0042130; P:negative regulation of T cell proliferation; IMP:MGI. DR GO; GO:0032689; P:negative regulation of type II interferon production; IMP:MGI. DR GO; GO:0001808; P:negative regulation of type IV hypersensitivity; IMP:MGI. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IMP:MGI. DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IMP:MGI. DR GO; GO:0050863; P:regulation of T cell activation; IMP:MGI. DR GO; GO:0043029; P:T cell homeostasis; IMP:MGI. DR GO; GO:0042098; P:T cell proliferation; IMP:MGI. DR CDD; cd00063; FN3; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 2. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR015373; Interferon/interleukin_rcp_dom. DR InterPro; IPR050650; Type-II_Cytokine-TF_Rcpt. DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1. DR PANTHER; PTHR20859:SF48; INTERLEUKIN-20 RECEPTOR SUBUNIT BETA; 1. DR Pfam; PF09294; Interfer-bind; 1. DR Pfam; PF01108; Tissue_fac; 1. DR SUPFAM; SSF49265; Fibronectin type III; 2. DR PROSITE; PS50853; FN3; 1. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..26 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 27..308 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003245856" FT TRANSMEM 226..249 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 32..137 FT /note="Fibronectin type-III" FT /evidence="ECO:0000259|PROSITE:PS50853" SQ SEQUENCE 308 AA; 34392 MW; 64B8D7F67287579B CRC64; MISQGVWTSP FMWFFYSMTS GFLTDAVSVL PAPQNLSVQS TNMKHLLMWN PVTQPGETVL YCVEYQGEYE SLYMSHIWIP SSQCSPTKSL ECDVTDDITA TVPYNFRVKA MLGSQTSAWS NLEHPFNRNA TVLTPPRMEV TEHGLHLVIE LEDLGPQFEF LVVYWRREPG AAEHVKMVRS GDIPVHLETM EPGAMYCVKA QALVKAIGRH SAFSQPTCVE MQGESLPLAL ALFAFVGFML ILVVVLLSVW KMGQLLRYSC CPAVVLPDTL KITSSSQKLI SCRKEEVDAC AVAVLSSEHL FGVWISQT //