ID E9Q6I8_MOUSE Unreviewed; 49 AA. AC E9Q6I8; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 28-JUN-2023, entry version 67. DE SubName: Full=DOT1-like, histone H3 methyltransferase (S. cerevisiae) {ECO:0000313|Ensembl:ENSMUSP00000130408.2}; GN Name=Dot1l {ECO:0000313|Ensembl:ENSMUSP00000130408.2, GN ECO:0000313|MGI:MGI:2143886}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130408.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130408.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130408.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000130408.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130408.2}; RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; E9Q6I8; -. DR SMR; E9Q6I8; -. DR MaxQB; E9Q6I8; -. DR ProteomicsDB; 371537; -. DR Antibodypedia; 22937; 582 antibodies from 32 providers. DR Ensembl; ENSMUST00000127740.8; ENSMUSP00000130408.2; ENSMUSG00000061589.15. DR AGR; MGI:2143886; -. DR MGI; MGI:2143886; Dot1l. DR VEuPathDB; HostDB:ENSMUSG00000061589; -. DR GeneTree; ENSGT00390000013515; -. DR HOGENOM; CLU_3142641_0_0_1; -. DR ChiTaRS; Dot1l; mouse. DR Proteomes; UP000000589; Chromosome 10. DR Bgee; ENSMUSG00000061589; Expressed in cerebellar cortex and 223 other tissues. DR ExpressionAtlas; E9Q6I8; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0032991; C:protein-containing complex; ISO:MGI. DR GO; GO:0031151; F:histone H3K79 methyltransferase activity; IBA:GO_Central. DR GO; GO:0042054; F:histone methyltransferase activity; IDA:MGI. DR GO; GO:0003676; F:nucleic acid binding; ISO:MGI. DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:MGI. DR GO; GO:0003713; F:transcription coactivator activity; ISO:MGI. DR GO; GO:0000077; P:DNA damage checkpoint signaling; IBA:GO_Central. DR GO; GO:0006281; P:DNA repair; IBA:GO_Central. DR GO; GO:0010467; P:gene expression; IDA:MGI. DR GO; GO:0034729; P:histone H3-K79 methylation; ISO:MGI. DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI. DR GO; GO:0046425; P:regulation of receptor signaling pathway via JAK-STAT; ISO:MGI. DR GO; GO:2000677; P:regulation of transcription regulatory region DNA binding; ISO:MGI. DR Gene3D; 1.10.260.60; -; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|EPD:E9Q6I8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 49 AA; 5526 MW; 0A6E88099E965C30 CRC64; MGEKLELRLK SPVGAEPAVY PWPLPVYDKH HDAAHEIIET IRGRALHSP //