ID E9Q6I8_MOUSE Unreviewed; 49 AA. AC E9Q6I8; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 13-FEB-2019, entry version 48. DE SubName: Full=DOT1-like, histone H3 methyltransferase (S. cerevisiae) {ECO:0000313|Ensembl:ENSMUSP00000130408}; GN Name=Dot1l {ECO:0000313|Ensembl:ENSMUSP00000130408, GN ECO:0000313|MGI:MGI:2143886}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130408, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130408, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130408, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000130408} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130408}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC166937; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9Q6I8; -. DR SMR; E9Q6I8; -. DR MaxQB; E9Q6I8; -. DR PRIDE; E9Q6I8; -. DR Ensembl; ENSMUST00000127740; ENSMUSP00000130408; ENSMUSG00000061589. DR MGI; MGI:2143886; Dot1l. DR eggNOG; KOG3924; Eukaryota. DR eggNOG; ENOG410XSYC; LUCA. DR GeneTree; ENSGT00390000013515; -. DR Reactome; R-MMU-3214841; PKMTs methylate histone lysines. DR ChiTaRS; Dot1l; mouse. DR Proteomes; UP000000589; Chromosome 10. DR Bgee; ENSMUSG00000061589; Expressed in 237 organ(s), highest expression level in brain. DR ExpressionAtlas; E9Q6I8; baseline and differential. DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; ISO:MGI. DR GO; GO:0032991; C:protein-containing complex; ISO:MGI. DR GO; GO:0042054; F:histone methyltransferase activity; IDA:MGI. DR GO; GO:0031151; F:histone methyltransferase activity (H3-K79 specific); IBA:GO_Central. DR GO; GO:0018024; F:histone-lysine N-methyltransferase activity; ISO:MGI. DR GO; GO:0008134; F:transcription factor binding; ISO:MGI. DR GO; GO:0006348; P:chromatin silencing at telomere; IBA:GO_Central. DR GO; GO:0000077; P:DNA damage checkpoint; IBA:GO_Central. DR GO; GO:0034729; P:histone H3-K79 methylation; ISO:MGI. DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI. DR GO; GO:0046425; P:regulation of receptor signaling pathway via JAK-STAT; ISO:MGI. DR GO; GO:2000677; P:regulation of transcription regulatory region DNA binding; ISO:MGI. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|EPD:E9Q6I8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 49 AA; 5526 MW; 0A6E88099E965C30 CRC64; MGEKLELRLK SPVGAEPAVY PWPLPVYDKH HDAAHEIIET IRGRALHSP //