ID E9Q6I8_MOUSE Unreviewed; 49 AA. AC E9Q6I8; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 05-JUL-2017, entry version 41. DE SubName: Full=DOT1-like, histone H3 methyltransferase (S. cerevisiae) {ECO:0000313|Ensembl:ENSMUSP00000130408}; GN Name=Dot1l {ECO:0000313|Ensembl:ENSMUSP00000130408, GN ECO:0000313|MGI:MGI:2143886}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130408, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130408, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130408, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000130408} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130408}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000130408}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC166937; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9Q6I8; -. DR SMR; E9Q6I8; -. DR MaxQB; E9Q6I8; -. DR PaxDb; E9Q6I8; -. DR Ensembl; ENSMUST00000127740; ENSMUSP00000130408; ENSMUSG00000061589. DR MGI; MGI:2143886; Dot1l. DR eggNOG; KOG3924; Eukaryota. DR eggNOG; ENOG410XSYC; LUCA. DR GeneTree; ENSGT00390000013515; -. DR Reactome; R-MMU-3214841; PKMTs methylate histone lysines. DR ChiTaRS; Dot1l; mouse. DR Proteomes; UP000000589; Chromosome 10. DR Bgee; ENSMUSG00000061589; -. DR ExpressionAtlas; E9Q6I8; baseline and differential. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; ISO:MGI. DR GO; GO:0043234; C:protein complex; ISO:MGI. DR GO; GO:0042054; F:histone methyltransferase activity; IDA:MGI. DR GO; GO:0018024; F:histone-lysine N-methyltransferase activity; ISO:MGI. DR GO; GO:0008134; F:transcription factor binding; ISO:MGI. DR GO; GO:0034729; P:histone H3-K79 methylation; ISO:MGI. DR GO; GO:0008284; P:positive regulation of cell proliferation; ISO:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI. DR GO; GO:0046425; P:regulation of JAK-STAT cascade; ISO:MGI. DR GO; GO:2000677; P:regulation of transcription regulatory region DNA binding; ISO:MGI. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 49 AA; 5526 MW; 0A6E88099E965C30 CRC64; MGEKLELRLK SPVGAEPAVY PWPLPVYDKH HDAAHEIIET IRGRALHSP //