ID E9Q6I8_MOUSE Unreviewed; 49 AA. AC E9Q6I8; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 09-DEC-2015, entry version 29. DE SubName: Full=Protein Dot1l {ECO:0000313|Ensembl:ENSMUSP00000130408}; GN Name=Dot1l {ECO:0000313|Ensembl:ENSMUSP00000130408, GN ECO:0000313|MGI:MGI:2143886}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130408, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130408, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130408, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000130408} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130408}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000130408}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC166937; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9Q6I8; -. DR SMR; E9Q6I8; 4-42. DR STRING; 10090.ENSMUSP00000100973; -. DR PaxDb; E9Q6I8; -. DR Ensembl; ENSMUST00000127740; ENSMUSP00000130408; ENSMUSG00000061589. DR MGI; MGI:2143886; Dot1l. DR eggNOG; ENOG410XSYC; LUCA. DR eggNOG; KOG3924; Eukaryota. DR GeneTree; ENSGT00390000013515; -. DR Reactome; R-MMU-3214841; PKMTs methylate histone lysines. DR ChiTaRS; Dot1l; mouse. DR NextBio; 35555367; -. DR Proteomes; UP000000589; Chromosome 10. DR Bgee; E9Q6I8; -. DR ExpressionAtlas; E9Q6I8; baseline and differential. DR GO; GO:0042054; F:histone methyltransferase activity; IDA:MGI. DR GO; GO:0031151; F:histone methyltransferase activity (H3-K79 specific); IEA:InterPro. DR GO; GO:0018024; F:histone-lysine N-methyltransferase activity; ISO:MGI. DR GO; GO:0008134; F:transcription factor binding; ISO:MGI. DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro. DR GO; GO:0046425; P:regulation of JAK-STAT cascade; ISO:MGI. DR GO; GO:2000677; P:regulation of transcription regulatory region DNA binding; ISO:MGI. DR InterPro; IPR030445; H3-K79_meTrfase. DR PANTHER; PTHR21451; PTHR21451; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:E9Q6I8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. SQ SEQUENCE 49 AA; 5526 MW; 0A6E88099E965C30 CRC64; MGEKLELRLK SPVGAEPAVY PWPLPVYDKH HDAAHEIIET IRGRALHSP //