ID E9Q559_MOUSE Unreviewed; 1026 AA. AC E9Q559; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 11-NOV-2015, entry version 41. DE RecName: Full=Calcium-transporting ATPase {ECO:0000256|RuleBase:RU361146}; DE EC=3.6.3.8 {ECO:0000256|RuleBase:RU361146}; GN Name=Atp2a3 {ECO:0000313|Ensembl:ENSMUSP00000127036, GN ECO:0000313|MGI:MGI:1194503}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000127036, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000127036, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000127036, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000127036} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000127036}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis CC of ATP coupled with the transport of calcium. CC {ECO:0000256|RuleBase:RU361146}. CC -!- CATALYTIC ACTIVITY: ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate CC + Ca(2+)(Side 2). {ECO:0000256|RuleBase:RU361146}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361146}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361146}. CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC CC 3.A.3) family. Type IIA subfamily. CC {ECO:0000256|RuleBase:RU361146}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|RuleBase:RU361146}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000127036}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL663082; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL670399; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX284667; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001156809.1; NM_001163337.1. DR UniGene; Mm.6306; -. DR ProteinModelPortal; E9Q559; -. DR SMR; E9Q559; 1-994. DR STRING; 10090.ENSMUSP00000021142; -. DR MaxQB; E9Q559; -. DR PaxDb; E9Q559; -. DR Ensembl; ENSMUST00000163326; ENSMUSP00000127036; ENSMUSG00000020788. DR GeneID; 53313; -. DR UCSC; uc011xym.1; mouse. DR CTD; 489; -. DR MGI; MGI:1194503; Atp2a3. DR eggNOG; KOG0202; Eukaryota. DR eggNOG; COG0474; LUCA. DR GeneTree; ENSGT00810000125366; -. DR ChiTaRS; Atp2a3; mouse. DR NextBio; 310097; -. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; E9Q559; -. DR ExpressionAtlas; E9Q559; baseline and differential. DR Genevisible; E9Q559; MM. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0016529; C:sarcoplasmic reticulum; ISO:MGI. DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0005388; F:calcium-transporting ATPase activity; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:InterPro. DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central. DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central. DR Gene3D; 1.20.1110.10; -; 2. DR Gene3D; 2.70.150.10; -; 2. DR Gene3D; 3.40.1110.10; -; 1. DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C. DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N. DR InterPro; IPR023299; ATPase_P-typ_cyto_domN. DR InterPro; IPR018303; ATPase_P-typ_P_site. DR InterPro; IPR023298; ATPase_P-typ_TM_dom. DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A. DR InterPro; IPR023214; HAD-like_dom. DR InterPro; IPR005782; P-type_ATPase_IIA. DR InterPro; IPR001757; P_typ_ATPase. DR InterPro; IPR030330; SERCA3. DR PANTHER; PTHR24093:SF295; PTHR24093:SF295; 2. DR Pfam; PF00689; Cation_ATPase_C; 1. DR Pfam; PF00690; Cation_ATPase_N; 1. DR Pfam; PF00122; E1-E2_ATPase; 1. DR Pfam; PF08282; Hydrolase_3; 1. DR PRINTS; PR00119; CATATPASE. DR SMART; SM00831; Cation_ATPase_N; 1. DR SUPFAM; SSF56784; SSF56784; 1. DR SUPFAM; SSF81660; SSF81660; 1. DR TIGRFAMs; TIGR01116; ATPase-IIA1_Ca; 1. DR TIGRFAMs; TIGR01494; ATPase_P-type; 2. DR PROSITE; PS00154; ATPASE_E1_E2; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|RuleBase:RU361146, KW ECO:0000256|SAAS:SAAS00092325}; KW Calcium {ECO:0000256|RuleBase:RU361146}; KW Calcium transport {ECO:0000256|RuleBase:RU361146}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Hydrolase {ECO:0000256|RuleBase:RU361146, KW ECO:0000256|SAAS:SAAS00318102}; KW Ion transport {ECO:0000256|RuleBase:RU361146}; KW Membrane {ECO:0000256|RuleBase:RU361146, KW ECO:0000256|SAAS:SAAS00092451}; KW Nucleotide-binding {ECO:0000256|RuleBase:RU361146, KW ECO:0000256|SAAS:SAAS00092336}; KW Proteomics identification {ECO:0000213|MaxQB:E9Q559, KW ECO:0000213|PeptideAtlas:E9Q559}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|RuleBase:RU361146, KW ECO:0000256|SAAS:SAAS00092309}; KW Transmembrane helix {ECO:0000256|RuleBase:RU361146, KW ECO:0000256|SAAS:SAAS00092306}; KW Transport {ECO:0000256|RuleBase:RU361146}. FT TRANSMEM 60 78 Helical. {ECO:0000256|RuleBase:RU361146}. FT TRANSMEM 84 107 Helical. {ECO:0000256|RuleBase:RU361146}. FT TRANSMEM 260 280 Helical. {ECO:0000256|RuleBase:RU361146}. FT TRANSMEM 292 321 Helical. {ECO:0000256|RuleBase:RU361146}. FT TRANSMEM 760 781 Helical. {ECO:0000256|RuleBase:RU361146}. FT TRANSMEM 833 857 Helical. {ECO:0000256|RuleBase:RU361146}. FT TRANSMEM 932 957 Helical. {ECO:0000256|RuleBase:RU361146}. SQ SEQUENCE 1026 AA; 112504 MW; E8EC0928C4E8F278 CRC64; MEEAHLLSAA DVLRRFSVTA EGGLSLEQVT DARERYGPNE LPTEEGKSLW ELVVEQFEDL LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL TGESVSVTKH TDAIPDPRAV NQDKKNMLFS GTNIASGKAL GVAVATGLQT ELGKIRSQMA AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ MSVCRMFVVA EAEAGTCRLH EFTISGTTYT PEGEVRQGEQ PVRCGQFDGL VELATICALC NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLK GLSRVERAGA CNSVIKQLMR KEFTLEFSRD RKSMSVYCTP TRADPKVQGS KMFVKGAPES VIERCSSVRV GSRTAPLSTT SREHILAKIR DWGSGSDTLR CLALATRDTP PRKEDMHLDD CSRFVQYETD LTFVGCVGML DPPRPEVAAC ITRCSRAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVLG KAYTGREFDD LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAI LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKP PRNPREALIS GWLFFRYLAI GVYVGLATVA AATWWFLYDT EGPQVTFYQL RNFLKCSEDN PLFAGIDCKV FESRFPTTMA LSVLVTIEMC NALNSVSENQ SLLRMPPWLN PWLLGAVVMS MALHFLILLV PPLPLIFQVT PLSGRQWGVV LQMSLPVILL DEALKYLSRN HMDGVLGTFM QARSRQLPTT SRTPYHTGLA SWKKRT //