ID CTSG1_MOUSE Reviewed; 1151 AA. AC E9Q355; E9PW02; E9QAY8; Q3V0A1; Q8C9D6; Q8CAA4; Q8R5F0; DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot. DT 05-APR-2011, sequence version 1. DT 02-OCT-2024, entry version 74. DE RecName: Full=Cation channel sperm-associated protein subunit gamma 1; DE Flags: Precursor; GN Name=Catsperg1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5). RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, Testis, and Thymus; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). RC STRAIN=FVB/N; TISSUE=Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I CC membrane protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=6; CC Name=1; CC IsoId=E9Q355-1; Sequence=Displayed; CC Name=2; CC IsoId=E9Q355-2; Sequence=VSP_042991; CC Name=3; CC IsoId=E9Q355-3; Sequence=VSP_042983, VSP_042991, VSP_042994; CC Name=4; CC IsoId=E9Q355-4; Sequence=VSP_042986, VSP_042987, VSP_042989, CC VSP_042990; CC Name=5; CC IsoId=E9Q355-5; Sequence=VSP_042987, VSP_042988, VSP_042992, CC VSP_042993; CC Name=6; CC IsoId=E9Q355-6; Sequence=VSP_042984, VSP_042985, VSP_042989, CC VSP_042990; CC -!- SIMILARITY: Belongs to the CATSPERG family. {ECO:0000305}. CC -!- CAUTION: Despite its name, it is unclear whether the protein is part of CC some Catsper complex: in contrast to Catsperg2, it has not been CC identified in the Catsper complex and its expression is not restricted CC to testis tissues. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK039202; BAC30276.1; -; mRNA. DR EMBL; AK042364; BAC31237.1; -; mRNA. DR EMBL; AK133307; BAE21603.1; -; mRNA. DR EMBL; AC164564; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC022688; AAH22688.1; -; mRNA. DR CCDS; CCDS52170.1; -. [E9Q355-2] DR CCDS; CCDS90197.1; -. [E9Q355-1] DR RefSeq; NP_001158130.1; NM_001164658.1. [E9Q355-2] DR RefSeq; XP_006540154.1; XM_006540091.3. [E9Q355-1] DR AlphaFoldDB; E9Q355; -. DR SMR; E9Q355; -. DR STRING; 10090.ENSMUSP00000045233; -. DR GlyCosmos; E9Q355; 1 site, No reported glycans. DR GlyGen; E9Q355; 1 site. DR PhosphoSitePlus; E9Q355; -. DR SwissPalm; E9Q355; -. DR jPOST; E9Q355; -. DR PaxDb; 10090-ENSMUSP00000129837; -. DR PeptideAtlas; E9Q355; -. DR ProteomicsDB; 285223; -. [E9Q355-1] DR ProteomicsDB; 285224; -. [E9Q355-2] DR ProteomicsDB; 285225; -. [E9Q355-3] DR ProteomicsDB; 285227; -. [E9Q355-5] DR Ensembl; ENSMUST00000047846.13; ENSMUSP00000045233.7; ENSMUSG00000049676.15. [E9Q355-2] DR Ensembl; ENSMUST00000069861.4; ENSMUSP00000067388.4; ENSMUSG00000049676.15. [E9Q355-4] DR Ensembl; ENSMUST00000164653.8; ENSMUSP00000131827.2; ENSMUSG00000049676.15. [E9Q355-5] DR Ensembl; ENSMUST00000169143.8; ENSMUSP00000129837.2; ENSMUSG00000049676.15. [E9Q355-1] DR GeneID; 320225; -. DR KEGG; mmu:320225; -. DR UCSC; uc009gbe.1; mouse. [E9Q355-4] DR UCSC; uc012fhe.1; mouse. [E9Q355-2] DR AGR; MGI:2443617; -. DR CTD; 320225; -. DR MGI; MGI:2443617; Catsperg1. DR VEuPathDB; HostDB:ENSMUSG00000049676; -. DR eggNOG; ENOG502QWAR; Eukaryota. DR GeneTree; ENSGT00390000014139; -. DR HOGENOM; CLU_010744_0_0_1; -. DR InParanoid; E9Q355; -. DR OMA; SCSITWA; -. DR OrthoDB; 2916483at2759; -. DR PhylomeDB; E9Q355; -. DR TreeFam; TF337337; -. DR Reactome; R-MMU-1300642; Sperm Motility And Taxes. DR BioGRID-ORCS; 320225; 1 hit in 61 CRISPR screens. DR ChiTaRS; Catsperg1; mouse. DR PRO; PR:E9Q355; -. DR Proteomes; UP000000589; Chromosome 7. DR RNAct; E9Q355; protein. DR Bgee; ENSMUSG00000049676; Expressed in testis and 59 other cell types or tissues. DR ExpressionAtlas; E9Q355; baseline and differential. DR GO; GO:0036128; C:CatSper complex; IBA:GO_Central. DR GO; GO:0031514; C:motile cilium; IBA:GO_Central. DR GO; GO:0097228; C:sperm principal piece; IEA:InterPro. DR InterPro; IPR028246; CATSPERG. DR InterPro; IPR053871; CATSPERG_b-prop. DR InterPro; IPR053873; CATSPERG_C. DR InterPro; IPR053874; CATSPERG_Ig-like. DR InterPro; IPR053872; CATSPERG_N. DR PANTHER; PTHR14327:SF1; CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT GAMMA; 1. DR PANTHER; PTHR14327; CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT GAMMA; 1. DR Pfam; PF15064; CATSPERG_beta-prop; 1. DR Pfam; PF22846; CATSPERG_C; 1. DR Pfam; PF22851; CATSPERG_Ig-like; 1. DR Pfam; PF22840; CATSPERG_NTD; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal; KW Transmembrane; Transmembrane helix. FT SIGNAL 1..38 FT /evidence="ECO:0000255" FT CHAIN 39..1151 FT /note="Cation channel sperm-associated protein subunit FT gamma 1" FT /id="PRO_0000416886" FT TOPO_DOM 39..1063 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 1064..1084 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 1085..1151 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 1113..1151 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1113..1132 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 356 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 1..120 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_042983" FT VAR_SEQ 1..6 FT /note="Missing (in isoform 6)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_042984" FT VAR_SEQ 57..276 FT /note="Missing (in isoform 6)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_042985" FT VAR_SEQ 57..91 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_042986" FT VAR_SEQ 110..276 FT /note="Missing (in isoform 4 and isoform 5)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_042987" FT VAR_SEQ 380..399 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_042988" FT VAR_SEQ 401..418 FT /note="KNCSIDWATYITDERNLL -> THFFLCVWGIWNRRVVGL (in isoform FT 4 and isoform 6)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:16141072" FT /id="VSP_042989" FT VAR_SEQ 419..1151 FT /note="Missing (in isoform 4 and isoform 6)" FT /evidence="ECO:0000303|PubMed:15489334, FT ECO:0000303|PubMed:16141072" FT /id="VSP_042990" FT VAR_SEQ 534..586 FT /note="Missing (in isoform 2 and isoform 3)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_042991" FT VAR_SEQ 534..546 FT /note="IWYFLEGGYDVYQ -> ELQDDHLHQHVPF (in isoform 5)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_042992" FT VAR_SEQ 547..1151 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_042993" FT VAR_SEQ 974..1151 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:16141072" FT /id="VSP_042994" FT CONFLICT E9Q355-6:178..179 FT /note="FL -> VCV (in Ref. 3; AAH22688)" FT /evidence="ECO:0000305" FT CONFLICT E9Q355-6:182 FT /note="W -> C (in Ref. 3; AAH22688)" FT /evidence="ECO:0000305" SQ SEQUENCE 1151 AA; 132352 MW; B9EDB8C0034A3F4B CRC64; MVSRPAMSPV SPVWPRKPNL WAFWVLRLVL LLSLKSWAED TLQHCTWLLV LNKFEKVGLH LSKDRFQDHE PIDTVAKVFQ KLTDSPIDPS ENYLSFPYYL QINFSCPGQN SEELARKGHL MGMKPMVRIN YMYSVNFYRW EMENLQILME AAPMRSTGYC PAEAMCILNW YTPMPFKNGS VVSSVDIYTN GIGPFIPKKR FYVNMNGFLK RDASGKSLFA IGYESLVLKS SHFRLSKSRP LWYTVNHAPV FILGGFYDEK AILFSDSNFQ DYVLLELSID SCWVGSFYCP ILGFSATIHD AIATESTLFI RQNQLVYYFT GTYSTLFDKS HGSSRWVRVL PSECIKRLCP VYFSGNGSEY VLALTTGKNE GYIHIGTITD GLVSFEMVPD GWSVCEKLPG KNCSIDWATY ITDERNLLLL VKIDSGQFYL VNFNTEFKTL NILYKIPEFI PEAKELDFLV LLDTVTYTNT PMTPKGLFFN TLNNMLYIWG NFILQSYNRE EFIFLADFPK ESTIKYMVNS FKGQMAVVTE NEEIWYFLEG GYDVYQVVPS QGWRTYLKLQ KMQKSPLYST NESLVSLFYQ DENLFQLVYL FDVGKERLVK RLLPVGTLME YNLPKPFTVV NQGNYKMITF TNTCPFKAIH AVDVPKKQHA SRTESYVALP PLVSESLGFH NNNTLAVYQG LVYYLLWLHS KYDKPYADPV HDPTWRWWQH KTKDKDYFFY LFSNRLAAEG IYINMNAYQK LYNMSGDYGI PDLFFLDKGN WFTFTVVLLS HQDTFTSSDS QGPTINVDKK LSLSLVLADP ECLSVTATRE FLLNRNTLLT KIKVIDKKRC SEQGMVGRNI KKTSMLIKVL GAPGNCIQRT YLGDHIQGIR LVPIFIGCPP GKRLAFDVSY TIKHSEEINK HYFDCVIKDA EMPCFLFRDL FQPFFLVQDL VTGDSGSFLG SYVLKVVGGG RTLNTIRDYT EEEIFRYNSP LDTTNSLIWK TKVERTTEDK KFYIMSHESP GVEWLCLENS PCYDIIPQSI YPPEFFFKLL VSNRGVDNST YCDYKLTFIV HIHGLPLSSK RSSFIVMVST SFFIALVVFY ILFCLVWPHI VKAWVSFRWK IHNMMAPETY SSSSSSGGFT LHSHSSEGSF EGPSRPGTKE DNVQAKRAKV A //