ID E9Q2L8_MOUSE Unreviewed; 91 AA. AC E9Q2L8; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 2. DT 02-OCT-2024, entry version 77. DE SubName: Full=Gamma-aminobutyric acid type A receptor subunit alpha 1 {ECO:0000313|Ensembl:ENSMUSP00000129056.3}; DE Flags: Fragment; GN Name=Gabra1 {ECO:0000313|Ensembl:ENSMUSP00000129056.3, GN ECO:0000313|MGI:MGI:95613}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000129056.3, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000129056.3, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129056.3, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000129056.3} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129056.3}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000129056.3} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129056.3}; RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; E9Q2L8; -. DR SMR; E9Q2L8; -. DR PeptideAtlas; E9Q2L8; -. DR ProteomicsDB; 314136; -. DR Antibodypedia; 4533; 558 antibodies from 44 providers. DR Ensembl; ENSMUST00000153147.3; ENSMUSP00000129056.3; ENSMUSG00000010803.14. DR AGR; MGI:95613; -. DR MGI; MGI:95613; Gabra1. DR VEuPathDB; HostDB:ENSMUSG00000010803; -. DR GeneTree; ENSGT00940000159136; -. DR HOGENOM; CLU_010920_5_5_1; -. DR OMA; YLWAYLF; -. DR ChiTaRS; Gabra1; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000010803; Expressed in cerebellum lobe and 172 other cell types or tissues. DR ExpressionAtlas; E9Q2L8; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro. DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro. DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1. DR InterPro; IPR001390; GABAAa_rcpt. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR Pfam; PF02931; Neur_chan_LBD; 1. DR PRINTS; PR01079; GABAARALPHA. DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1. PE 4: Predicted; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..27 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 28..91 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5006724073" FT DOMAIN 42..91 FT /note="Neurotransmitter-gated ion-channel ligand-binding" FT /evidence="ECO:0000259|Pfam:PF02931" FT NON_TER 91 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000129056.3" SQ SEQUENCE 91 AA; 10450 MW; F828A2C1C2E6F401 CRC64; MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD GYDNRLRPGL GERVTEVKTD IFVTSFGPVS DHDMEYTIDV F //