ID E9Q2L8_MOUSE Unreviewed; 91 AA. AC E9Q2L8; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 2. DT 02-DEC-2020, entry version 59. DE SubName: Full=Gamma-aminobutyric acid receptor subunit alpha-1 {ECO:0000313|Ensembl:ENSMUSP00000129056}; DE Flags: Fragment; GN Name=Gabra1 {ECO:0000313|Ensembl:ENSMUSP00000129056, GN ECO:0000313|MGI:MGI:95613}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000129056, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000129056, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129056, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000129056} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000129056}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL645751; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL645752; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; E9Q2L8; -. DR PeptideAtlas; E9Q2L8; -. DR PRIDE; E9Q2L8; -. DR Antibodypedia; 4533; 473 antibodies. DR Ensembl; ENSMUST00000153147; ENSMUSP00000129056; ENSMUSG00000010803. DR MGI; MGI:95613; Gabra1. DR GeneTree; ENSGT00940000159136; -. DR HOGENOM; CLU_010920_5_5_1; -. DR OMA; ELHKPAM; -. DR ChiTaRS; Gabra1; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000010803; Expressed in cerebellum and 212 other tissues. DR ExpressionAtlas; E9Q2L8; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR001390; GABAAa_rcpt. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR PRINTS; PR01079; GABAARALPHA. DR SUPFAM; SSF63712; SSF63712; 1. PE 4: Predicted; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..27 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 28..91 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5006724073" FT DOMAIN 42..91 FT /note="Neur_chan_LBD" FT /evidence="ECO:0000259|Pfam:PF02931" FT NON_TER 91 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000129056" SQ SEQUENCE 91 AA; 10450 MW; F828A2C1C2E6F401 CRC64; MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD GYDNRLRPGL GERVTEVKTD IFVTSFGPVS DHDMEYTIDV F //