ID E9PWE3_MOUSE Unreviewed; 645 AA. AC E9PWE3; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 28-JUN-2023, entry version 80. DE SubName: Full=Transcription factor 3 {ECO:0000313|Ensembl:ENSMUSP00000100978.2}; GN Name=Tcf3 {ECO:0000313|Ensembl:ENSMUSP00000100978.2, GN ECO:0000313|MGI:MGI:98510}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000100978.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000100978.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100978.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0007829|PubMed:24129315} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24129315; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M., RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V., RA Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000100978.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100978.2}; RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; E9PWE3; -. DR SMR; E9PWE3; -. DR jPOST; E9PWE3; -. DR MaxQB; E9PWE3; -. DR PeptideAtlas; E9PWE3; -. DR ProteomicsDB; 306429; -. DR Antibodypedia; 4332; 648 antibodies from 46 providers. DR Ensembl; ENSMUST00000105341.8; ENSMUSP00000100978.2; ENSMUSG00000020167.15. DR AGR; MGI:98510; -. DR MGI; MGI:98510; Tcf3. DR VEuPathDB; HostDB:ENSMUSG00000020167; -. DR GeneTree; ENSGT00940000157036; -. DR ChiTaRS; Tcf3; mouse. DR Proteomes; UP000000589; Chromosome 10. DR Bgee; ENSMUSG00000020167; Expressed in ventricular zone and 249 other tissues. DR ExpressionAtlas; E9PWE3; baseline and differential. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR CDD; cd18943; bHLH_E-protein_E47-like; 1. DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR036638; HLH_DNA-bd_sf. DR PANTHER; PTHR11793; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR; 1. DR PANTHER; PTHR11793:SF7; TRANSCRIPTION FACTOR E2-ALPHA; 1. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1. DR PROSITE; PS50888; BHLH; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|EPD:E9PWE3, KW ECO:0007829|MaxQB:E9PWE3}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 540..593 FT /note="BHLH" FT /evidence="ECO:0000259|PROSITE:PS50888" FT REGION 32..107 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 126..208 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 339..375 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 454..528 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 50..92 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 126..155 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 339..361 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 454..472 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 489..528 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 645 AA; 67103 MW; EC88146F49974ED1 CRC64; MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG LPSSVYPPSS GDSYSRDAAA YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM LGDGSSPLPL APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT SGHTPPVSGA AAESLLGTTA SSSGDALGKA LASIYSPDHS SNNFSPSPST PVGSPQGLPG TSQWPRAGAP SALSPNYDAG LHGLSKMEDR LDEAIHVLRS HAVGTASDLH GLLPGHGALT TSFTGPMSLG GRHAGLVGGS HPEEGLTSGA SLLHNHASLP SQPSSLPDLS QRPPDSYSGL GRAGTTAGAS EIKREEKEDE EIASVADAEE DKKDLKVPRT RTSSTDEVLS LEEKDLRDRE RRMANNARER VRVRDINEAF RELGRMCQLH LKSDKAQTKL LILQQAVQVI LGLEQQVRER NLNPKAACLK RREEEKVSGV VGDPQLALSA AHPGLGEAHN PAGHL //