ID E9PWE3_MOUSE Unreviewed; 645 AA. AC E9PWE3; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 09-DEC-2015, entry version 40. DE SubName: Full=Transcription factor E2-alpha {ECO:0000313|Ensembl:ENSMUSP00000100978}; GN Name=Tcf3 {ECO:0000313|Ensembl:ENSMUSP00000100978, GN ECO:0000313|MGI:MGI:98510}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000100978, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000100978, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100978, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000100978} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100978}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. CC {ECO:0000256|RuleBase:RU000367}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000100978}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC152062; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; E9PWE3; -. DR SMR; E9PWE3; 2-38, 533-605. DR STRING; 10090.ENSMUSP00000100979; -. DR PaxDb; E9PWE3; -. DR Ensembl; ENSMUST00000105341; ENSMUSP00000100978; ENSMUSG00000020167. DR MGI; MGI:98510; Tcf3. DR eggNOG; ENOG410XYUA; LUCA. DR eggNOG; KOG3910; Eukaryota. DR GeneTree; ENSGT00510000046438; -. DR ChiTaRS; Tcf3; mouse. DR NextBio; 35554006; -. DR Proteomes; UP000000589; Chromosome 10. DR Bgee; E9PWE3; -. DR ExpressionAtlas; E9PWE3; baseline and differential. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0000790; C:nuclear chromatin; ISO:MGI. DR GO; GO:0000788; C:nuclear nucleosome; IDA:MGI. DR GO; GO:0005654; C:nucleoplasm; ISO:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0043234; C:protein complex; ISO:MGI. DR GO; GO:0090575; C:RNA polymerase II transcription factor complex; ISO:MGI. DR GO; GO:0005667; C:transcription factor complex; IDA:MGI. DR GO; GO:0043425; F:bHLH transcription factor binding; ISO:MGI. DR GO; GO:0003682; F:chromatin binding; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0070888; F:E-box binding; ISO:MGI. DR GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:MGI. DR GO; GO:0042803; F:protein homodimerization activity; IDA:MGI. DR GO; GO:0070491; F:repressing transcription factor binding; ISO:MGI. DR GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; ISO:MGI. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI. DR GO; GO:0003713; F:transcription coactivator activity; ISO:MGI. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISO:MGI. DR GO; GO:0008134; F:transcription factor binding; ISO:MGI. DR GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding; ISO:MGI. DR GO; GO:0070644; F:vitamin D response element binding; ISO:MGI. DR GO; GO:0002326; P:B cell lineage commitment; ISO:MGI. DR GO; GO:0048468; P:cell development; IGI:MGI. DR GO; GO:0043966; P:histone H3 acetylation; IMP:MGI. DR GO; GO:0043967; P:histone H4 acetylation; IMP:MGI. DR GO; GO:0033152; P:immunoglobulin V(D)J recombination; IMP:MGI. DR GO; GO:0030098; P:lymphocyte differentiation; IMP:MGI. DR GO; GO:0001779; P:natural killer cell differentiation; IGI:MGI. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISO:MGI. DR GO; GO:0048541; P:Peyer's patch development; IGI:MGI. DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISO:MGI. DR GO; GO:0045787; P:positive regulation of cell cycle; ISO:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI. DR GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISO:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IGI:MGI. DR GO; GO:0050821; P:protein stabilization; IDA:MGI. DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; ISO:MGI. DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI. DR GO; GO:0042493; P:response to drug; IMP:MGI. DR GO; GO:0032496; P:response to lipopolysaccharide; IMP:MGI. DR GO; GO:0033077; P:T cell differentiation in thymus; IMP:MGI. DR GO; GO:0006351; P:transcription, DNA-templated; ISO:MGI. DR Gene3D; 4.10.280.10; -; 1. DR InterPro; IPR011598; bHLH_dom. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; SSF47459; 1. DR PROSITE; PS50888; BHLH; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:E9PWE3, KW ECO:0000213|PeptideAtlas:E9PWE3}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 540 593 BHLH (basic helix-loop-helix). FT {ECO:0000259|PROSITE:PS50888}. SQ SEQUENCE 645 AA; 67103 MW; EC88146F49974ED1 CRC64; MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG LPSSVYPPSS GDSYSRDAAA YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM LGDGSSPLPL APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT SGHTPPVSGA AAESLLGTTA SSSGDALGKA LASIYSPDHS SNNFSPSPST PVGSPQGLPG TSQWPRAGAP SALSPNYDAG LHGLSKMEDR LDEAIHVLRS HAVGTASDLH GLLPGHGALT TSFTGPMSLG GRHAGLVGGS HPEEGLTSGA SLLHNHASLP SQPSSLPDLS QRPPDSYSGL GRAGTTAGAS EIKREEKEDE EIASVADAEE DKKDLKVPRT RTSSTDEVLS LEEKDLRDRE RRMANNARER VRVRDINEAF RELGRMCQLH LKSDKAQTKL LILQQAVQVI LGLEQQVRER NLNPKAACLK RREEEKVSGV VGDPQLALSA AHPGLGEAHN PAGHL //