ID E9PWE3_MOUSE Unreviewed; 645 AA. AC E9PWE3; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 09-JAN-2013, entry version 17. DE SubName: Full=Transcription factor E2-alpha; GN Name=Tcf3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] RP IDENTIFICATION. RC STRAIN=C57BL/6J; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC152062; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR IPI; IPI00831609; -. DR ProteinModelPortal; E9PWE3; -. DR SMR; E9PWE3; 541-600. DR Ensembl; ENSMUST00000105341; ENSMUSP00000100978; ENSMUSG00000020167. DR MGI; MGI:98510; Tcf3. DR GeneTree; ENSGT00510000046438; -. DR Bgee; E9PWE3; -. DR GO; GO:0000788; C:nuclear nucleosome; IDA:MGI. DR GO; GO:0005667; C:transcription factor complex; IDA:MGI. DR GO; GO:0003682; F:chromatin binding; IDA:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI. DR GO; GO:0042803; F:protein homodimerization activity; IDA:MGI. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI. DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:MGI. DR GO; GO:0048468; P:cell development; IGI:MGI. DR GO; GO:0043966; P:histone H3 acetylation; IMP:MGI. DR GO; GO:0043967; P:histone H4 acetylation; IMP:MGI. DR GO; GO:0033152; P:immunoglobulin V(D)J recombination; IMP:MGI. DR GO; GO:0001779; P:natural killer cell differentiation; IGI:MGI. DR GO; GO:0048541; P:Peyer's patch development; IGI:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0050821; P:protein stabilization; IDA:MGI. DR GO; GO:0042493; P:response to drug; IMP:MGI. DR GO; GO:0032496; P:response to lipopolysaccharide; IMP:MGI. DR GO; GO:0033077; P:T cell differentiation in thymus; IMP:MGI. DR Gene3D; 4.10.280.10; HLH_DNA_bd; 1. DR InterPro; IPR011598; HLH_dom. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; HLH_basic; 1. DR PROSITE; PS50888; HLH; 1. PE 4: Predicted; KW Complete proteome; Reference proteome. SQ SEQUENCE 645 AA; 67103 MW; EC88146F49974ED1 CRC64; MMNQSQRMAP VGSDKELSDL LDFSMMFPLP VANGKSRPAS LGGTQFAGSG LEDRPSSGSW GSSDQNSSSF DPSRTYSEGA HFSDSHSSLP PSTFLGAGLG GKGSERNAYA TFGRDTSVGT LSQAGFLPGE LSLSSPGPLS PSGIKSSSQY YPSFPSNPRR RAADGGLDTQ PKKVRKVPPG LPSSVYPPSS GDSYSRDAAA YPSAKTPSSA YPSPFYVADG SLHPSAELWS TPSQVGFGPM LGDGSSPLPL APGSSSVGSG TFGGLQQQDR MGYQLHGSEV NGSLPAVSSF SAAPGTYSGT SGHTPPVSGA AAESLLGTTA SSSGDALGKA LASIYSPDHS SNNFSPSPST PVGSPQGLPG TSQWPRAGAP SALSPNYDAG LHGLSKMEDR LDEAIHVLRS HAVGTASDLH GLLPGHGALT TSFTGPMSLG GRHAGLVGGS HPEEGLTSGA SLLHNHASLP SQPSSLPDLS QRPPDSYSGL GRAGTTAGAS EIKREEKEDE EIASVADAEE DKKDLKVPRT RTSSTDEVLS LEEKDLRDRE RRMANNARER VRVRDINEAF RELGRMCQLH LKSDKAQTKL LILQQAVQVI LGLEQQVRER NLNPKAACLK RREEEKVSGV VGDPQLALSA AHPGLGEAHN PAGHL //