ID E9PPC8_HUMAN Unreviewed; 132 AA. AC E9PPC8; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 29-MAY-2024, entry version 74. DE RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273}; DE EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273}; DE Flags: Fragment; GN Name=PPP3CA {ECO:0000313|Ensembl:ENSP00000434599.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434599.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000434599.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000434599.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:61977; EC=3.1.3.16; CC Evidence={ECO:0000256|RuleBase:RU004273}; CC -!- SIMILARITY: Belongs to the PPP phosphatase family. CC {ECO:0000256|RuleBase:RU004273}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC092671; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP001816; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP001870; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AP001939; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC876894; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; E9PPC8; -. DR SMR; E9PPC8; -. DR MassIVE; E9PPC8; -. DR MaxQB; E9PPC8; -. DR PeptideAtlas; E9PPC8; -. DR ProteomicsDB; 22680; -. DR Antibodypedia; 2193; 678 antibodies from 44 providers. DR Ensembl; ENST00000525819.1; ENSP00000434599.1; ENSG00000138814.17. DR UCSC; uc062ynp.1; human. DR HGNC; HGNC:9314; PPP3CA. DR VEuPathDB; HostDB:ENSG00000138814; -. DR GeneTree; ENSGT00940000156306; -. DR HOGENOM; CLU_004962_0_9_1; -. DR OMA; YPAACNF; -. DR ChiTaRS; PPP3CA; human. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000138814; Expressed in Brodmann (1909) area 23 and 209 other cell types or tissues. DR ExpressionAtlas; E9PPC8; baseline and differential. DR GO; GO:0005955; C:calcineurin complex; IEA:TreeGrafter. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0005516; F:calmodulin binding; IEA:TreeGrafter. DR GO; GO:0033192; F:calmodulin-dependent protein phosphatase activity; IEA:InterPro. DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC. DR GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:TreeGrafter. DR Gene3D; 3.60.21.10; -; 1. DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH. DR InterPro; IPR029052; Metallo-depent_PP-like. DR InterPro; IPR043360; PP2B. DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase. DR PANTHER; PTHR45673:SF5; PROTEIN PHOSPHATASE 3 CATALYTIC SUBUNIT ALPHA; 1. DR PANTHER; PTHR45673; SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED; 1. DR Pfam; PF00149; Metallophos; 1. DR PRINTS; PR00114; STPHPHTASE. DR SMART; SM00156; PP2Ac; 1. DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1. DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 1. PE 1: Evidence at protein level; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004273}; KW Proteomics identification {ECO:0007829|EPD:E9PPC8, KW ECO:0007829|MaxQB:E9PPC8}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 97..102 FT /note="Serine/threonine specific protein phosphatases" FT /evidence="ECO:0000259|PROSITE:PS00125" FT NON_TER 132 FT /evidence="ECO:0000313|Ensembl:ENSP00000434599.1" SQ SEQUENCE 132 AA; 15365 MW; CCFBE838E59A709A CRC64; MKEGRLEESV ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD AF //