ID   E9PFI2_HUMAN            Unreviewed;      1162 AA.
AC   E9PFI2;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   13-SEP-2023, entry version 87.
DE   SubName: Full=Syntaxin binding protein 5L {ECO:0000313|Ensembl:ENSP00000420019.1};
GN   Name=STXBP5L {ECO:0000313|Ensembl:ENSP00000420019.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000420019.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000420019.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0007829|PubMed:22814378}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [3] {ECO:0000313|Ensembl:ENSP00000420019.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm
CC       {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}.
CC   -!- SIMILARITY: Belongs to the WD repeat L(2)GL family.
CC       {ECO:0000256|ARBA:ARBA00008070}.
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DR   EMBL; AC072026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC078854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC078857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC112483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC128659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E9PFI2; -.
DR   SMR; E9PFI2; -.
DR   MaxQB; E9PFI2; -.
DR   PeptideAtlas; E9PFI2; -.
DR   ProteomicsDB; 20108; -.
DR   Antibodypedia; 32817; 6 antibodies from 5 providers.
DR   DNASU; 9515; -.
DR   Ensembl; ENST00000471454.6; ENSP00000420019.1; ENSG00000145087.14.
DR   MANE-Select; ENST00000471454.6; ENSP00000420019.1; NM_001308330.2; NP_001295259.1.
DR   UCSC; uc011bji.3; human.
DR   CTD; 9515; -.
DR   HGNC; HGNC:30757; STXBP5L.
DR   VEuPathDB; HostDB:ENSG00000145087; -.
DR   GeneTree; ENSGT00950000182906; -.
DR   OMA; KFNRERX; -.
DR   OrthoDB; 415950at2759; -.
DR   BioGRID-ORCS; 9515; 16 hits in 1151 CRISPR screens.
DR   ChiTaRS; STXBP5L; human.
DR   GenomeRNAi; 9515; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000145087; Expressed in Brodmann (1909) area 23 and 103 other tissues.
DR   ExpressionAtlas; E9PFI2; baseline and differential.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR   GO; GO:0098992; C:neuronal dense core vesicle; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
DR   CDD; cd15893; R-SNARE_STXBP5; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR000664; Lethal2_giant.
DR   InterPro; IPR013905; Lgl_C_dom.
DR   InterPro; IPR013577; LLGL2.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10241; LETHAL 2 GIANT LARVAE PROTEIN; 1.
DR   PANTHER; PTHR10241:SF19; SYNTAXIN-BINDING PROTEIN 5-LIKE; 1.
DR   Pfam; PF08596; Lgl_C; 1.
DR   Pfam; PF08366; LLGL; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PRINTS; PR00962; LETHAL2GIANT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF58038; SNARE fusion complex; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS50892; V_SNARE; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU00290};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Proteomics identification {ECO:0007829|MaxQB:E9PFI2,
KW   ECO:0007829|PeptideAtlas:E9PFI2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          107..148
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          246..287
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          1097..1157
FT                   /note="V-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50892"
FT   REGION          15..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          722..747
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        726..747
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1162 AA;  128948 MW;  3714B91621A67D1C CRC64;
     MKKFNFRKVL DGLTASSPGS GSSSGSNSGG GAGSGSVHPA GTAGVLREEI QETLTSEYFQ
     ICKTVRHGFP HQPTALAFDP VQKILAIGTR TGAIRILGRP GVDCYCQHES GAAVLQLQFL
     INEGALVSAS SDDTLHLWNL RQKRPAILHS LKFNRERITY CHLPFQSKWL YVGTERGNTH
     IVNIESFILS GYVIMWNKAI ELSTKTHPGP VVHLSDSPRD EGKLLIGYEN GTVVFWDLKS
     KRAELRVYYD EAIHSIDWHH EGKQFMCSHS DGSLTLWNLK SPSRPFQTTI PHGKSQREGR
     KSESCKPILK VEYKTCKNSE PFIIFSGGLS YDKACRRPSL TIMHGKAITV LEMDHPIVEF
     LTLCETPYPN EFQEPYAVVV LLEKDLIVVD LTQSNFPIFE NPYPMDIHES PVTCTAYFAD
     CPPDLILVLY SIGVKHKKQG YSNKEWPISG GAWNLGAQTY PEIIITGHAD GSIKFWDASA
     ITLQMLYKLK TSKVFEKQKV GEGKQTCEIV EEDPFAIQMI YWCPESRIFC VSGVSAYVII
     YKFSRHEITT EIVSLEVRLQ YDVEDIITPE PETSPPFPDL SAQLPSSRSL SGSTNTVASE
     GVTKDSIPCL NVKTRPVRMP PGYQAELVIQ LVWVDGEPPQ QITSLAVSSA YGIVAFGNCN
     GLAVVDFIQK TVLLSMGTID LYRSSDLYQR QPRSPRKNKQ FIAGLTELND SPVPLELERC
     KSPTSDHVNG HCTSPTSQSC SSGKRLSSAD VSKVNRWGPG RPPFRKAQSA ACMEISLPVT
     TEENRENSYN RSRSSSISSI DKDSKEAITA LYFMDSFARK NDSTISPCLF VGTSLGMVLI
     ISLNLPLADE QRFTEPVMVL PSGTFLSLKG AVLTFSCMDR MGGLMQPPYE VWRDPNNIDE
     NEKSWRRKVV MNSSSASQEI GDHQYTIICS EKQAKVFSLP SQTCLYVHNI TETSFILQAN
     VVVMCSSACL ACFCANGHIM IMSLPSLRPM LDVNYLPLTD MRIARTFCFT NEGQALYLVS
     PTEIQRLTYS QEMCDNLQDM LGDLFTPIET PEAQNRGFLK GLFGGSGQTF DREELFGEAS
     AGKASRSLAQ HIPGPGSIEG MKGAAGGVMG ELTRARIALD ERGQRLGELE EKTAGMMTSA
     EAFSKHAHEL MLKYKDKKWY QF
//