ID E9PFG6_HUMAN Unreviewed; 97 AA. AC E9PFG6; A1IMF2; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 2. DT 02-OCT-2024, entry version 51. DE RecName: Full=Heparanase {ECO:0000256|ARBA:ARBA00040414}; DE EC=3.2.1.166 {ECO:0000256|ARBA:ARBA00039100}; DE Flags: Fragment; GN Name=HPSE {ECO:0000313|EMBL:CAF28887.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAF28887.1}; RN [1] {ECO:0000313|EMBL:CAF28887.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Fetal kidney {ECO:0000313|EMBL:CAF28887.1}; RA Quiros L.M.; RT "Identification of a new heparanase spliced variant in human fetal RT kidney."; RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan CC sulfate chains in heparan sulfate proteoglycan.; EC=3.2.1.166; CC Evidence={ECO:0000256|ARBA:ARBA00036917}; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 79 family. CC {ECO:0000256|ARBA:ARBA00009800}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ627581; CAF28887.1; -; mRNA. DR AlphaFoldDB; E9PFG6; -. DR PeptideAtlas; E9PFG6; -. DR ProteomicsDB; 20097; -. DR ChiTaRS; HPSE; human. DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:InterPro. DR GO; GO:0060055; P:angiogenesis involved in wound healing; IEA:TreeGrafter. DR GO; GO:0007160; P:cell-matrix adhesion; IEA:TreeGrafter. DR Gene3D; 3.20.20.80; Glycosidases; 1. DR InterPro; IPR005199; Glyco_hydro_79. DR InterPro; IPR017853; Glycoside_hydrolase_SF. DR PANTHER; PTHR46145; HEPARANASE; 1. DR PANTHER; PTHR46145:SF3; HEPARANASE; 1. DR Pfam; PF03662; Glyco_hydro_79n; 1. DR SUPFAM; SSF51445; (Trans)glycosidases; 1. PE 2: Evidence at transcript level; KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; KW Signal {ECO:0000256|ARBA:ARBA00022729}. FT NON_TER 97 FT /evidence="ECO:0000313|EMBL:CAF28887.1" SQ SEQUENCE 97 AA; 10338 MW; F7CFAFE472BCF2BB CRC64; MLLLLGPLGP LSPGALPRPA QAQDVVDLDF FTQEPLHLVS PSFLSVTRPG KKVWLGETSS AYGGGAPLLS DTFAAGFMWL DKLGLSARMG IEVVMRQ //