ID E9PC45_HUMAN Unreviewed; 93 AA. AC E9PC45; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 07-APR-2021, entry version 80. DE RecName: Full=Glycoprotein IIIb {ECO:0000256|ARBA:ARBA00019032}; DE AltName: Full=PAS IV {ECO:0000256|ARBA:ARBA00019279}; DE AltName: Full=PAS-4 {ECO:0000256|ARBA:ARBA00020635}; DE AltName: Full=Platelet glycoprotein 4 {ECO:0000256|ARBA:ARBA00020772}; DE AltName: Full=Platelet glycoprotein IV {ECO:0000256|ARBA:ARBA00020781}; DE Flags: Fragment; GN Name=CD36 {ECO:0000313|Ensembl:ENSP00000409762}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409762, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000409762, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000409762} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSP00000398760} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0007829|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in); CC Xref=Rhea:RHEA:33655, ChEBI:CHEBI:30823; CC Evidence={ECO:0000256|ARBA:ARBA00000626}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:33656; CC Evidence={ECO:0000256|ARBA:ARBA00000626}; CC -!- CATALYTIC ACTIVITY: CC Reaction=(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)- CC octadecadienoate(in); Xref=Rhea:RHEA:45264, ChEBI:CHEBI:30245; CC Evidence={ECO:0000256|ARBA:ARBA00000542}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45265; CC Evidence={ECO:0000256|ARBA:ARBA00000542}; CC -!- CATALYTIC ACTIVITY: CC Reaction=butanoate(out) = butanoate(in); Xref=Rhea:RHEA:45248, CC ChEBI:CHEBI:17968; Evidence={ECO:0000256|ARBA:ARBA00001892}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45249; CC Evidence={ECO:0000256|ARBA:ARBA00001892}; CC -!- CATALYTIC ACTIVITY: CC Reaction=hexadecanoate(out) = hexadecanoate(in); Xref=Rhea:RHEA:45256, CC ChEBI:CHEBI:7896; Evidence={ECO:0000256|ARBA:ARBA00000934}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45257; CC Evidence={ECO:0000256|ARBA:ARBA00000934}; CC -!- CATALYTIC ACTIVITY: CC Reaction=tetracosanoate(out) = tetracosanoate(in); CC Xref=Rhea:RHEA:45260, ChEBI:CHEBI:31014; CC Evidence={ECO:0000256|ARBA:ARBA00023949}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45261; CC Evidence={ECO:0000256|ARBA:ARBA00023949}; CC -!- CATALYTIC ACTIVITY: CC Reaction=tetradecanoate(out) = tetradecanoate(in); CC Xref=Rhea:RHEA:45252, ChEBI:CHEBI:30807; CC Evidence={ECO:0000256|ARBA:ARBA00000996}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45253; CC Evidence={ECO:0000256|ARBA:ARBA00000996}; CC -!- SUBCELLULAR LOCATION: Apical cell membrane CC {ECO:0000256|ARBA:ARBA00004221}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651}. Golgi apparatus CC {ECO:0000256|ARBA:ARBA00004555}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the CD36 family. CC {ECO:0000256|ARBA:ARBA00010532}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC004862; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC073182; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC073850; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092108; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC124834; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458491; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458494; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteomicsDB; 19362; -. DR Antibodypedia; 659; 1708 antibodies. DR Ensembl; ENST00000428497; ENSP00000409762; ENSG00000135218. DR Ensembl; ENST00000436384; ENSP00000398760; ENSG00000135218. DR UCSC; uc064evh.1; human. DR HGNC; HGNC:1663; CD36. DR OpenTargets; ENSG00000135218; -. DR VEuPathDB; HostDB:ENSG00000135218.17; -. DR GeneTree; ENSGT00940000153372; -. DR HOGENOM; CLU_186465_0_0_1; -. DR ChiTaRS; CD36; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000135218; Expressed in adipose tissue and 213 other tissues. DR ExpressionAtlas; E9PC45; baseline and differential. DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR InterPro; IPR005428; CD36/SCARB1/SNMP1. DR InterPro; IPR033076; CD36_chordates. DR InterPro; IPR002159; CD36_fam. DR PANTHER; PTHR11923; PTHR11923; 1. DR PANTHER; PTHR11923:SF12; PTHR11923:SF12; 1. DR Pfam; PF01130; CD36; 1. DR PRINTS; PR01610; CD36ANTIGEN. DR PRINTS; PR01609; CD36FAMILY. PE 1: Evidence at protein level; KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Proteomics identification {ECO:0007829|MaxQB:E9PC45, KW ECO:0007829|PeptideAtlas:E9PC45, ECO:0007829|ProteomicsDB:E9PC45}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT TRANSMEM 7..29 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT NON_TER 93 FT /evidence="ECO:0000313|Ensembl:ENSP00000409762" SQ SEQUENCE 93 AA; 10338 MW; F598F88009B62E81 CRC64; MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTY //