ID E9PB93_HUMAN Unreviewed; 104 AA. AC E9PB93; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 29-MAY-2024, entry version 77. DE SubName: Full=RNA polymerase II subunit D {ECO:0000313|Ensembl:ENSP00000387117.1}; GN Name=POLR2D {ECO:0000313|Ensembl:ENSP00000387117.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387117.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000387117.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000387117.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the eukaryotic RPB4 RNA polymerase subunit CC family. {ECO:0000256|ARBA:ARBA00025724}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC006011; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC012306; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; E9PB93; -. DR SMR; E9PB93; -. DR MassIVE; E9PB93; -. DR MaxQB; E9PB93; -. DR PeptideAtlas; E9PB93; -. DR ProteomicsDB; 19173; -. DR Antibodypedia; 33469; 206 antibodies from 28 providers. DR Ensembl; ENST00000409698.1; ENSP00000387117.1; ENSG00000144231.11. DR UCSC; uc061nrf.1; human. DR HGNC; HGNC:9191; POLR2D. DR VEuPathDB; HostDB:ENSG00000144231; -. DR GeneTree; ENSGT00390000004912; -. DR HOGENOM; CLU_110332_2_1_1; -. DR ChiTaRS; POLR2D; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000144231; Expressed in endothelial cell and 185 other cell types or tissues. DR ExpressionAtlas; E9PB93; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0016607; C:nuclear speck; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0005665; C:RNA polymerase II, core complex; IEA:TreeGrafter. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0031369; F:translation initiation factor binding; IEA:TreeGrafter. DR GO; GO:0034402; P:recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; IEA:TreeGrafter. DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:TreeGrafter. DR Gene3D; 1.20.1250.40; -; 1. DR InterPro; IPR010997; HRDC-like_sf. DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core. DR InterPro; IPR045222; Rpb4-like. DR InterPro; IPR005574; Rpb4/RPC9. DR InterPro; IPR038324; Rpb4/RPC9_sf. DR PANTHER; PTHR21297; DNA-DIRECTED RNA POLYMERASE II; 1. DR PANTHER; PTHR21297:SF0; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4; 1. DR Pfam; PF03874; RNA_pol_Rpb4; 1. DR SMART; SM00657; RPOL4c; 1. DR SUPFAM; SSF47819; HRDC-like; 1. PE 1: Evidence at protein level; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|EPD:E9PB93, KW ECO:0007829|MaxQB:E9PB93}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}. FT DOMAIN 1..103 FT /note="RNA polymerase Rpb4/RPC9 core" FT /evidence="ECO:0000259|SMART:SM00657" SQ SEQUENCE 104 AA; 12267 MW; 674DBFAE68FEED82 CRC64; MLLEHRKQQN ESAEDEQELS EVFMKTLNYT ARFSRFKNRE TIASVRSLLL QKKLHKFELA CLANLCPETA EESKALIPSL EGRFEDEELQ QILDDIQTKR SFQY //