ID E9PB93_HUMAN Unreviewed; 104 AA. AC E9PB93; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 07-APR-2021, entry version 62. DE SubName: Full=DNA-directed RNA polymerase II subunit RPB4 {ECO:0000313|Ensembl:ENSP00000387117}; GN Name=POLR2D {ECO:0000313|Ensembl:ENSP00000387117}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387117, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000387117, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000387117} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC006011; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC012306; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; E9PB93; -. DR PeptideAtlas; E9PB93; -. DR PRIDE; E9PB93; -. DR ProteomicsDB; 19173; -. DR Antibodypedia; 33469; 186 antibodies. DR Ensembl; ENST00000409698; ENSP00000387117; ENSG00000144231. DR UCSC; uc061nrf.1; human. DR HGNC; HGNC:9191; POLR2D. DR OpenTargets; ENSG00000144231; -. DR VEuPathDB; HostDB:ENSG00000144231.10; -. DR GeneTree; ENSGT00390000004912; -. DR HOGENOM; CLU_110332_2_1_1; -. DR ChiTaRS; POLR2D; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000144231; Expressed in testis and 213 other tissues. DR ExpressionAtlas; E9PB93; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0016607; C:nuclear speck; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0030880; C:RNA polymerase complex; IEA:InterPro. DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro. DR Gene3D; 1.20.1250.40; -; 1. DR InterPro; IPR010997; HRDC-like_sf. DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core. DR InterPro; IPR005574; RPB4/RPC9. DR InterPro; IPR038324; Rpb4/RPC9_sf. DR Pfam; PF03874; RNA_pol_Rpb4; 1. DR SMART; SM00657; RPOL4c; 1. DR SUPFAM; SSF47819; SSF47819; 1. PE 1: Evidence at protein level; KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|EPD:E9PB93, KW ECO:0007829|MaxQB:E9PB93}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}. FT DOMAIN 1..103 FT /note="RPOL4c" FT /evidence="ECO:0000259|SMART:SM00657" SQ SEQUENCE 104 AA; 12267 MW; 674DBFAE68FEED82 CRC64; MLLEHRKQQN ESAEDEQELS EVFMKTLNYT ARFSRFKNRE TIASVRSLLL QKKLHKFELA CLANLCPETA EESKALIPSL EGRFEDEELQ QILDDIQTKR SFQY //