ID   E9M263_HUMAN            Unreviewed;        57 AA.
AC   E9M263;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Hemoglobin beta chain {ECO:0000313|EMBL:ADW79453.1};
DE   Flags: Fragment;
GN   Name=HBB {ECO:0000313|EMBL:ADW79453.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ADW79453.1};
RN   [1] {ECO:0000313|EMBL:ADW79453.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Whole blood {ECO:0000313|EMBL:ADW79453.1};
RA   Zhuang L., Patel N., Vega R.A., Carmichael H., Tuan D.L., Kutlar A.,
RA   Kutlar F.;
RT   "A 468 bp deletion detected at the promoter region of beta-glibin gene,
RT   located at (- 475 to - 8) from CAP site, causing a high Hb A2 beta-
RT   thalassemia by removing the proximal regulatory elements of CAAT, TATA and
RT   CACCC boxes.";
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the globin family.
CC       {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238}.
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DR   EMBL; HQ174213; ADW79453.1; -; Genomic_DNA.
DR   AlphaFoldDB; E9M263; -.
DR   SMR; E9M263; -.
DR   PeptideAtlas; E9M263; -.
DR   ChiTaRS; HBB; human.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.10; Globins; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR11442:SF42; HEMOGLOBIN SUBUNIT BETA; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; Globin-like; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   3: Inferred from homology;
KW   Oxygen transport {ECO:0000256|ARBA:ARBA00022621};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transport {ECO:0000256|ARBA:ARBA00022621}.
FT   DOMAIN          2..57
FT                   /note="Globin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS01033"
FT   NON_TER         57
FT                   /evidence="ECO:0000313|EMBL:ADW79453.1"
SQ   SEQUENCE   57 AA;  6252 MW;  52C12A13A9D34F58 CRC64;
     MVHLTPEEKS AVTALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS TPDAVMG
//