ID E9LUX2_HUMAN Unreviewed; 71 AA. AC E9LUX2; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 31-JAN-2018, entry version 35. DE SubName: Full=Hemoglobin alpha-2 chain variant {ECO:0000313|EMBL:ADV90877.1}; DE Flags: Fragment; GN Name=HBA2 {ECO:0000313|EMBL:ADV90877.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ADV90877.1}; RN [1] {ECO:0000313|EMBL:ADV90877.1} RP NUCLEOTIDE SEQUENCE. RA Natarajan K., Patel N., Zhuang L., Carmichael H., Kutlar A., RA Kutlar F.; RT "Unstable Hb Questembert: (alpha-2/Ser 131 Pro); TCT 131 CCT, an RT alpha-2 globin gene mutation, detected in a black woman from Haiti RT that presented with hemolytic anemia."; RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000256|PROSITE- CC ProRule:PRU00238, ECO:0000256|RuleBase:RU000356, CC ECO:0000256|SAAS:SAAS00578531}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00238}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ141567; ADV90877.1; -; Genomic_DNA. DR UniGene; Hs.449630; -. DR UniGene; Hs.654744; -. DR PeptideAtlas; E9LUX2; -. DR eggNOG; KOG3378; Eukaryota. DR eggNOG; COG1018; LUCA. DR ChiTaRS; HBA2; human. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW. DR InterPro; IPR000971; Globin. DR InterPro; IPR009050; Globin-like_sf. DR InterPro; IPR002338; Haemoglobin_a-typ. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00612; ALPHAHAEM. DR SUPFAM; SSF46458; SSF46458; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 3: Inferred from homology; KW Heme {ECO:0000256|RuleBase:RU000356, ECO:0000256|SAAS:SAAS00514504}; KW Iron {ECO:0000256|SAAS:SAAS00514500}; KW Metal-binding {ECO:0000256|SAAS:SAAS00514495}; KW Oxygen transport {ECO:0000256|RuleBase:RU000356, KW ECO:0000256|SAAS:SAAS00514488}; KW Transport {ECO:0000256|RuleBase:RU000356, KW ECO:0000256|SAAS:SAAS00514490}. FT DOMAIN 1 71 GLOBIN. {ECO:0000259|PROSITE:PS01033}. FT NON_TER 1 1 {ECO:0000313|EMBL:ADV90877.1}. SQ SEQUENCE 71 AA; 7726 MW; 37F6105D12B10C24 CRC64; AHVDDMPNAL SALSDLHAHK LRVDPVNFKL LSHCLLVTLA AHLPAEFTPA VHASLDKFLA PVSTVLTSKY R //