ID E9L181_9HEMI Unreviewed; 216 AA. AC E9L181; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 21-SEP-2011, entry version 4. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=1.9.3.1; DE Flags: Fragment; GN Name=COI; OS Pseudococcus comstocki. OG Mitochondrion. OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidiformes; OC Coccoidea; Pseudococcidae; Pseudococcus. OX NCBI_TaxID=494596; RN [1] RP NUCLEOTIDE SEQUENCE. RX PubMed=21272395; DOI=10.1017/S0007485310000714; RA Park D.S., Suh S.J., Hebert P.D., Oh H.W., Hong K.J.; RT "DNA barcodes for two scale insect families, mealybugs (Hemiptera: RT Pseudococcidae) and armored scales (Hemiptera: Diaspididae)."; RL Bull. Entomol. Res. 0:0-0(2011). RN [2] RP NUCLEOTIDE SEQUENCE. RA Park D.-S., Oh H.-W., Suh S.-J.; RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM474352; ADK08814.1; -; Genomic_DNA. DR EMBL; HM474353; ADK08815.1; -; Genomic_DNA. DR EMBL; HM474354; ADK08816.1; -; Genomic_DNA. DR EMBL; HM474355; ADK08817.1; -; Genomic_DNA. DR EMBL; HM474356; ADK08818.1; -; Genomic_DNA. DR EMBL; HM474357; ADK08819.1; -; Genomic_DNA. DR EMBL; HM474360; ADK08822.1; -; Genomic_DNA. DR EMBL; HM474361; ADK08823.1; -; Genomic_DNA. DR EMBL; HM474364; ADK08826.1; -; Genomic_DNA. DR EMBL; HM474366; ADK08828.1; -; Genomic_DNA. DR EMBL; HM474367; ADK08829.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR InterPro; IPR000883; Cyt_c_Oxase_su1. DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom. DR Gene3D; G3DSA:1.20.210.10; COX1; 1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; COX1; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Respiratory chain; Transmembrane; Transport. FT NON_TER 1 1 FT NON_TER 216 216 SQ SEQUENCE 216 AA; 25076 MW; 942BEA517B2C45C7 CRC64; LMYLLFGFWS GLMGLSMSFI IRIELMNLNN NFNNNMIYYM MITIHAFMMI FFMTMPIIIG SLSNWLLPLM LMSSDLIFPR LNNFSFWLLI PSLILMMLNM FLNNNINTGW TLYPPLINQN YISLNFIIFS LHLNGISSIF SSINFISSIF IINNNNFLLN NSSLYIWSII ITTILLIISI PILSSAITMI ILDNNLNMNF FNPMGNGNPI LYQHLF //