ID E9L181_9HEMI Unreviewed; 216 AA. AC E9L181; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 11-DEC-2019, entry version 34. DE RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU000369}; DE EC=1.9.3.1 {ECO:0000256|RuleBase:RU000369}; DE Flags: Fragment; GN Name=COI {ECO:0000313|EMBL:ADK08814.1}; OS Pseudococcus comstocki. OG Mitochondrion {ECO:0000313|EMBL:ADK08814.1}. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Coccoidea; OC Pseudococcidae; Pseudococcus. OX NCBI_TaxID=494596 {ECO:0000313|EMBL:ADK08814.1}; RN [1] {ECO:0000313|EMBL:ADK08814.1} RP NUCLEOTIDE SEQUENCE. RA Park D.-S., Oh H.-W., Suh S.-J.; RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ADK08814.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21272395; DOI=10.1017/S0007485310000714; RA Park D.S., Suh S.J., Hebert P.D., Oh H.W., Hong K.J.; RT "DNA barcodes for two scale insect families, mealybugs (Hemiptera: RT Pseudococcidae) and armored scales (Hemiptera: Diaspididae)."; RL Bull. Entomol. Res. 0:0-0(2011). RN [3] {ECO:0000313|EMBL:AST10292.1} RP NUCLEOTIDE SEQUENCE. RA Ren J.-M., Ashfaq M., Hu X.-N., Ma J., Hebert P.D.N.; RT "Barcode Index Numbers Expedite Quarantine Inspections and Aid the RT Interception of Nonindigenous Mealybugs (Pseudococcidae)."; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1-3 CC form the functional core of the enzyme complex. CO I is the catalytic CC subunit of the enzyme. Electrons originating in cytochrome c are CC transferred via the copper A center of subunit 2 and heme A of subunit CC 1 to the bimetallic center formed by heme A3 and copper B. CC {ECO:0000256|RuleBase:RU000369}. CC -!- CATALYTIC ACTIVITY: CC Reaction=4 [Fe(II)cytochrome c] + 4 H(+) + O2 = 4 [Fe(III)cytochrome c] CC + 2 H2O; Xref=Rhea:RHEA:11436, Rhea:RHEA-COMP:10350, Rhea:RHEA- CC COMP:14399, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, CC ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.9.3.1; CC Evidence={ECO:0000256|RuleBase:RU000369}; CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC {ECO:0000256|RuleBase:RU000369}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU000369}. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000256|RuleBase:RU000369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HM474352; ADK08814.1; -; Genomic_DNA. DR EMBL; HM474353; ADK08815.1; -; Genomic_DNA. DR EMBL; HM474354; ADK08816.1; -; Genomic_DNA. DR EMBL; HM474355; ADK08817.1; -; Genomic_DNA. DR EMBL; HM474356; ADK08818.1; -; Genomic_DNA. DR EMBL; HM474357; ADK08819.1; -; Genomic_DNA. DR EMBL; HM474360; ADK08822.1; -; Genomic_DNA. DR EMBL; HM474361; ADK08823.1; -; Genomic_DNA. DR EMBL; HM474364; ADK08826.1; -; Genomic_DNA. DR EMBL; HM474366; ADK08828.1; -; Genomic_DNA. DR EMBL; HM474367; ADK08829.1; -; Genomic_DNA. DR EMBL; KY372433; AST10292.1; -; Genomic_DNA. DR EMBL; KY372445; AST10302.1; -; Genomic_DNA. DR EMBL; KY372548; AST10403.1; -; Genomic_DNA. DR EMBL; KY372630; AST10484.1; -; Genomic_DNA. DR EMBL; KY372673; AST10527.1; -; Genomic_DNA. DR EMBL; KY372745; AST10598.1; -; Genomic_DNA. DR EMBL; KY372824; AST10675.1; -; Genomic_DNA. DR EMBL; KY372830; AST10681.1; -; Genomic_DNA. DR EMBL; KY372859; AST10710.1; -; Genomic_DNA. DR EMBL; KY372915; AST10766.1; -; Genomic_DNA. DR EMBL; KY373034; AST10880.1; -; Genomic_DNA. DR UniPathway; UPA00705; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR023616; Cyt_c_oxase-like_su1_dom. DR InterPro; IPR036927; Cyt_c_oxase-like_su1_sf. DR InterPro; IPR000883; Cyt_C_Oxase_1. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper {ECO:0000256|RuleBase:RU000369}; KW Electron transport {ECO:0000256|RuleBase:RU000369}; KW Heme {ECO:0000256|RuleBase:RU000369}; Iron {ECO:0000256|RuleBase:RU000369}; KW Membrane {ECO:0000256|RuleBase:RU000369, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|RuleBase:RU000369}; KW Mitochondrion {ECO:0000256|RuleBase:RU000369, ECO:0000313|EMBL:ADK08814.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000369}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000369}; KW Respiratory chain {ECO:0000256|RuleBase:RU000369}; KW Transmembrane {ECO:0000256|RuleBase:RU000369, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000369}. FT TRANSMEM 6..25 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 37..64 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 84..102 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 123..152 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 164..192 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..216 FT /note="COX1" FT /evidence="ECO:0000259|PROSITE:PS50855" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ADK08814.1" FT NON_TER 216 FT /evidence="ECO:0000313|EMBL:ADK08814.1" SQ SEQUENCE 216 AA; 25076 MW; 942BEA517B2C45C7 CRC64; LMYLLFGFWS GLMGLSMSFI IRIELMNLNN NFNNNMIYYM MITIHAFMMI FFMTMPIIIG SLSNWLLPLM LMSSDLIFPR LNNFSFWLLI PSLILMMLNM FLNNNINTGW TLYPPLINQN YISLNFIIFS LHLNGISSIF SSINFISSIF IINNNNFLLN NSSLYIWSII ITTILLIISI PILSSAITMI ILDNNLNMNF FNPMGNGNPI LYQHLF //