ID   E9EA62_METAQ            Unreviewed;       418 AA.
AC   E9EA62;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   13-SEP-2023, entry version 45.
DE   RecName: Full=Ferrochelatase {ECO:0000256|RuleBase:RU000607};
DE            EC=4.98.1.1 {ECO:0000256|RuleBase:RU000607};
GN   ORFNames=MAC_06760 {ECO:0000313|EMBL:EFY87200.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY87200.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY87200.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX.
CC       {ECO:0000256|RuleBase:RU000607}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + heme b = Fe(2+) + protoporphyrin IX;
CC         Xref=Rhea:RHEA:22584, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:57306, ChEBI:CHEBI:60344; EC=4.98.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00034286,
CC         ECO:0000256|RuleBase:RU000607};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC       biosynthesis; protoheme from protoporphyrin-IX: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004943, ECO:0000256|RuleBase:RU000607}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU000607}.
CC   -!- SIMILARITY: Belongs to the ferrochelatase family.
CC       {ECO:0000256|ARBA:ARBA00007718, ECO:0000256|RuleBase:RU000607}.
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DR   EMBL; GL698531; EFY87200.1; -; Genomic_DNA.
DR   RefSeq; XP_007813100.1; XM_007814909.1.
DR   AlphaFoldDB; E9EA62; -.
DR   STRING; 92637.XP_007813100.1; -.
DR   GeneID; 19251071; -.
DR   KEGG; maw:MAC_06760; -.
DR   eggNOG; KOG1321; Eukaryota.
DR   HOGENOM; CLU_018884_1_0_1; -.
DR   InParanoid; E9EA62; -.
DR   OMA; LGDPYHC; -.
DR   OrthoDB; 5970at2759; -.
DR   UniPathway; UPA00252; UER00325.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004325; F:ferrochelatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00419; Ferrochelatase_C; 1.
DR   CDD; cd03411; Ferrochelatase_N; 1.
DR   Gene3D; 3.40.50.1400; -; 2.
DR   HAMAP; MF_00323; Ferrochelatase; 1.
DR   InterPro; IPR001015; Ferrochelatase.
DR   InterPro; IPR019772; Ferrochelatase_AS.
DR   InterPro; IPR033644; Ferrochelatase_C.
DR   InterPro; IPR033659; Ferrochelatase_N.
DR   NCBIfam; TIGR00109; hemH; 1.
DR   PANTHER; PTHR11108; FERROCHELATASE; 1.
DR   PANTHER; PTHR11108:SF1; FERROCHELATASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00762; Ferrochelatase; 1.
DR   SUPFAM; SSF53800; Chelatase; 1.
DR   PROSITE; PS00534; FERROCHELATASE; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133,
KW   ECO:0000256|RuleBase:RU000607};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000607};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000607};
KW   Membrane {ECO:0000256|RuleBase:RU000607};
KW   Mitochondrion {ECO:0000256|RuleBase:RU000607};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000607};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU000607};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499}.
SQ   SEQUENCE   418 AA;  46232 MW;  39EE7402E84D906A CRC64;
     MPSRICTQQL LRGLSRNSSS RLVTPQVATQ ARQFATPVPP VTQDATGSKG PTAMVFLNMG
     GPSKTDEVGD FLSRLFSDGD LIPLGRLQGY LGPLLSKRRT PMIQKQYAAI GGGSPIRKWS
     EYQSAEMCKI LDKTSPETAP HKPYVAFRYA DPLTEEMYQQ LLADGFGNGK GGRAVAFTQY
     PQYSCSTTGS SLNELWKWRQ RLEGKKVDES GEGTITWSVI DRWPAHSGLV EAFAQNIEAK
     LAEYPENRRK DVVLLFSAHS LPMSVVNRGD PYPGEVAATV YAVMERLKFS NPYRLCWQSQ
     VGPSAWLGPQ TATTVEQYVA KGQKNLVLIP IAFTSDHIET LYELDHEVIG ESGHTDTIKR
     ADSLNGSPVF IEALADIAKA HLRSGEACSK QMNLRCPSCR SERCTETKKF FARQQANL
//