ID E9EA62_METAQ Unreviewed; 418 AA. AC E9EA62; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 16-SEP-2015, entry version 21. DE RecName: Full=Ferrochelatase {ECO:0000256|RuleBase:RU000607}; DE EC=4.99.1.1 {ECO:0000256|RuleBase:RU000607}; GN ORFNames=MAC_06760 {ECO:0000313|EMBL:EFY87200.1}; OS Metarhizium acridum (strain CQMa 102). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; OC Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae; OC Metarhizium. OX NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499}; RN [1] {ECO:0000313|EMBL:EFY87200.1, ECO:0000313|Proteomes:UP000002499} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY87200.1, RC ECO:0000313|Proteomes:UP000002499}; RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264; RA Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., RA Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., RA Fang W., Wang S., Zhong Y., Ma L.-J., St Leger R.J., Zhao G.-P., RA Pei Y., Feng M.-G., Xia Y., Wang C.; RT "Genome sequencing and comparative transcriptomics of the model RT entomopathogenic fungi Metarhizium anisopliae and M. acridum."; RL PLoS Genet. 7:E1001264-E1001264(2011). CC -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX. CC {ECO:0000256|RuleBase:RU000607}. CC -!- CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+). CC {ECO:0000256|RuleBase:RU000607}. CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme CC biosynthesis; protoheme from protoporphyrin-IX: step 1/1. CC {ECO:0000256|RuleBase:RU000607}. CC -!- SIMILARITY: Belongs to the ferrochelatase family. CC {ECO:0000256|RuleBase:RU004185}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GL698531; EFY87200.1; -; Genomic_DNA. DR RefSeq; XP_007813100.1; XM_007814909.1. DR ProteinModelPortal; E9EA62; -. DR EnsemblFungi; EFY87200; EFY87200; MAC_06760. DR GeneID; 19251071; -. DR KEGG; maw:MAC_06760; -. DR InParanoid; E9EA62; -. DR KO; K01772; -. DR OrthoDB; EOG7V1G10; -. DR UniPathway; UPA00252; UER00325. DR Proteomes; UP000002499; Unassembled WGS sequence. DR GO; GO:0004325; F:ferrochelatase activity; IEA:UniProtKB-EC. DR GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW. DR HAMAP; MF_00323; Ferrochelatase; 1. DR InterPro; IPR001015; Ferrochelatase. DR InterPro; IPR019772; Ferrochelatase_AS. DR PANTHER; PTHR11108; PTHR11108; 1. DR Pfam; PF00762; Ferrochelatase; 1. DR TIGRFAMs; TIGR00109; hemH; 1. DR PROSITE; PS00534; FERROCHELATASE; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002499}; KW Heme biosynthesis {ECO:0000256|RuleBase:RU000607}; KW Iron {ECO:0000256|RuleBase:RU000607}; KW Lyase {ECO:0000256|RuleBase:RU000607}; KW Porphyrin biosynthesis {ECO:0000256|RuleBase:RU000607}; KW Reference proteome {ECO:0000313|Proteomes:UP000002499}. SQ SEQUENCE 418 AA; 46232 MW; 39EE7402E84D906A CRC64; MPSRICTQQL LRGLSRNSSS RLVTPQVATQ ARQFATPVPP VTQDATGSKG PTAMVFLNMG GPSKTDEVGD FLSRLFSDGD LIPLGRLQGY LGPLLSKRRT PMIQKQYAAI GGGSPIRKWS EYQSAEMCKI LDKTSPETAP HKPYVAFRYA DPLTEEMYQQ LLADGFGNGK GGRAVAFTQY PQYSCSTTGS SLNELWKWRQ RLEGKKVDES GEGTITWSVI DRWPAHSGLV EAFAQNIEAK LAEYPENRRK DVVLLFSAHS LPMSVVNRGD PYPGEVAATV YAVMERLKFS NPYRLCWQSQ VGPSAWLGPQ TATTVEQYVA KGQKNLVLIP IAFTSDHIET LYELDHEVIG ESGHTDTIKR ADSLNGSPVF IEALADIAKA HLRSGEACSK QMNLRCPSCR SERCTETKKF FARQQANL //