ID E9EA62_METAQ Unreviewed; 418 AA. AC E9EA62; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 31-MAY-2011, entry version 2. DE RecName: Full=Ferrochelatase; DE EC=4.99.1.1; GN ORFNames=MAC_06760; OS Metarhizium acridum (strain CQMa 102). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; OC Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae; OC mitosporic Clavicipitaceae; Metarhizium. OX NCBI_TaxID=655827; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CQMa 102; RX PubMed=21253567; DOI=10.1371/journal.pgen.1001264; RA Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., RA Hu X., Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., RA Wang S., Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., RA Feng M.G., Xia Y., Wang C.; RT "Genome sequencing and comparative transcriptomics of the model RT entomopathogenic fungi Metarhizium anisopliae and M. acridum."; RL PLoS Genet. 7:E1001264-E1001264(2011). CC -!- FUNCTION: Catalyzes the ferrous insertion into protoporphyrin IX CC (By similarity). CC -!- CATALYTIC ACTIVITY: Protoheme + 2 H(+) = protoporphyrin + Fe(2+). CC -!- PATHWAY: Porphyrin metabolism; protoheme biosynthesis; protoheme CC from protoporphyrin-IX: step 1/1. CC -!- SIMILARITY: Belongs to the ferrochelatase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GL698531; EFY87200.1; -; Genomic_DNA. DR GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro. DR GO; GO:0006783; P:heme biosynthetic process; IEA:InterPro. DR HAMAP; MF_00323; Ferrochelatase; 1; -. DR InterPro; IPR001015; Ferrochelatase. DR InterPro; IPR019772; Ferrochelatase_AS. DR PANTHER; PTHR11108; Ferrochelatase; 1. DR Pfam; PF00762; Ferrochelatase; 1. DR TIGRFAMs; TIGR00109; HemH; 1. DR PROSITE; PS00534; FERROCHELATASE; 1. PE 3: Inferred from homology; KW Complete proteome; Heme biosynthesis; Iron; Lyase; KW Porphyrin biosynthesis. SQ SEQUENCE 418 AA; 46232 MW; 39EE7402E84D906A CRC64; MPSRICTQQL LRGLSRNSSS RLVTPQVATQ ARQFATPVPP VTQDATGSKG PTAMVFLNMG GPSKTDEVGD FLSRLFSDGD LIPLGRLQGY LGPLLSKRRT PMIQKQYAAI GGGSPIRKWS EYQSAEMCKI LDKTSPETAP HKPYVAFRYA DPLTEEMYQQ LLADGFGNGK GGRAVAFTQY PQYSCSTTGS SLNELWKWRQ RLEGKKVDES GEGTITWSVI DRWPAHSGLV EAFAQNIEAK LAEYPENRRK DVVLLFSAHS LPMSVVNRGD PYPGEVAATV YAVMERLKFS NPYRLCWQSQ VGPSAWLGPQ TATTVEQYVA KGQKNLVLIP IAFTSDHIET LYELDHEVIG ESGHTDTIKR ADSLNGSPVF IEALADIAKA HLRSGEACSK QMNLRCPSCR SERCTETKKF FARQQANL //