ID TM216_DANRE Reviewed; 160 AA. AC E7EYQ9; DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot. DT 08-MAR-2011, sequence version 1. DT 02-OCT-2024, entry version 67. DE RecName: Full=Transmembrane protein 216; GN Name=tmem216; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] RP DISRUPTION PHENOTYPE. RX PubMed=22282472; DOI=10.1126/science.1213506; RA Lee J.H., Silhavy J.L., Lee J.E., Al-Gazali L., Thomas S., Davis E.E., RA Bielas S.L., Hill K.J., Iannicelli M., Brancati F., Gabriel S.B., Russ C., RA Logan C.V., Sharif S.M., Bennett C.P., Abe M., Hildebrandt F., Diplas B.H., RA Attie-Bitach T., Katsanis N., Rajab A., Koul R., Sztriha L., Waters E.R., RA Ferro-Novick S., Woods G.C., Johnson C.A., Valente E.M., Zaki M.S., RA Gleeson J.G.; RT "Evolutionarily assembled cis-regulatory module at a human ciliopathy RT locus."; RL Science 335:966-969(2012). CC -!- FUNCTION: Part of the tectonic-like complex which is required for CC tissue-specific ciliogenesis and may regulate ciliary membrane CC composition. {ECO:0000250}. CC -!- SUBUNIT: Part of the tectonic-like complex (also named B9 complex). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body CC {ECO:0000250}. Note=Localizes at the transition zone, a region between CC the basal body and the ciliary axoneme. {ECO:0000250}. CC -!- DISRUPTION PHENOTYPE: Ciliary phenotypes such as pericardial effusion, CC hydrocephalic brain, curved or kinked tail, gastrulation defects and CC other severe defects in left/right axis. {ECO:0000269|PubMed:22282472}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL645792; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; E7EYQ9; -. DR STRING; 7955.ENSDARP00000111752; -. DR TCDB; 9.B.204.1.2; the 4 tms ciliary biogenesis tmem17 (tmem17) family. DR PaxDb; 7955-ENSDARP00000111752; -. DR Ensembl; ENSDART00000131027; ENSDARP00000111752; ENSDARG00000091576. DR AGR; ZFIN:ZDB-GENE-100818-1; -. DR ZFIN; ZDB-GENE-100818-1; tmem216. DR eggNOG; KOG4502; Eukaryota. DR InParanoid; E7EYQ9; -. DR OMA; AEILMFV; -. DR PhylomeDB; E7EYQ9; -. DR TreeFam; TF323824; -. DR PRO; PR:E7EYQ9; -. DR Proteomes; UP000000437; Unplaced. DR Bgee; ENSDARG00000091576; Expressed in testis and 21 other cell types or tissues. DR ExpressionAtlas; E7EYQ9; baseline. DR GO; GO:0035869; C:ciliary transition zone; IBA:GO_Central. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB. DR GO; GO:0060027; P:convergent extension involved in gastrulation; IGI:ZFIN. DR GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central. DR GO; GO:0035845; P:photoreceptor cell outer segment organization; IMP:ZFIN. DR InterPro; IPR019184; Uncharacterised_TM-17. DR PANTHER; PTHR13531; GEO07735P1-RELATED-RELATED; 1. DR PANTHER; PTHR13531:SF5; TRANSMEMBRANE PROTEIN 216; 1. DR Pfam; PF09799; Transmemb_17; 1. PE 3: Inferred from homology; KW Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton; KW Membrane; Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..160 FT /note="Transmembrane protein 216" FT /id="PRO_0000416297" FT TRANSMEM 41..61 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 68..88 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 101..121 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 134..154 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 160 AA; 18216 MW; 86DF135F2268FCEF CRC64; MADVCLRLQY ACPWQSNMAA HGRQPVLSST PLQILFHLNG WYFAAFFVAE ILMFIYKGVI LPYPQDNLIL DVVLLLLFSG LETLRLFYGW KGNLCQRSLA LFVSVAILVP CAVLSVYYLL LQTFVLRLEF VLNAVLLCFY GFELVLGVMT ISIFSRANIY //