ID   E7ENA5_HUMAN            Unreviewed;       558 AA.
AC   E7ENA5; E7ETL4;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   27-NOV-2024, entry version 87.
DE   SubName: Full=Deleted in azoospermia 4 {ECO:0000313|Ensembl:ENSP00000371869.6};
GN   Name=DAZ4 {ECO:0000313|Ensembl:ENSP00000371869.6};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000371869.6, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000371869.6}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11237011; DOI=10.1038/35057062;
RG   International Human Genome Sequencing Consortium;
RA   Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J.,
RA   Devon K., Dewar K., Doyle M., FitzHugh W., Funke R., Gage D., Harris K.,
RA   Heaford A., Howland J., Kann L., Lehoczky J., LeVine R., McEwan P.,
RA   McKernan K., Meldrim J., Mesirov J.P., Miranda C., Morris W., Naylor J.,
RA   Raymond C., Rosetti M., Santos R., Sheridan A., Sougnez C.,
RA   Stange-Thomann N., Stojanovic N., Subramanian A., Wyman D., Rogers J.,
RA   Sulston J., Ainscough R., Beck S., Bentley D., Burton J., Clee C.,
RA   Carter N., Coulson A., Deadman R., Deloukas P., Dunham A., Dunham I.,
RA   Durbin R., French L., Grafham D., Gregory S., Hubbard T., Humphray S.,
RA   Hunt A., Jones M., Lloyd C., McMurray A., Matthews L., Mercer S., Milne S.,
RA   Mullikin J.C., Mungall A., Plumb R., Ross M., Shownkeen R., Sims S.,
RA   Waterston R.H., Wilson R.K., Hillier L.W., McPherson J.D., Marra M.A.,
RA   Mardis E.R., Fulton L.A., Chinwalla A.T., Pepin K.H., Gish W.R.,
RA   Chissoe S.L., Wendl M.C., Delehaunty K.D., Miner T.L., Delehaunty A.,
RA   Kramer J.B., Cook L.L., Fulton R.S., Johnson D.L., Minx P.J., Clifton S.W.,
RA   Hawkins T., Branscomb E., Predki P., Richardson P., Wenning S., Slezak T.,
RA   Doggett N., Cheng J.F., Olsen A., Lucas S., Elkin C., Uberbacher E.,
RA   Frazier M., Gibbs R.A., Muzny D.M., Scherer S.E., Bouck J.B.,
RA   Sodergren E.J., Worley K.C., Rives C.M., Gorrell J.H., Metzker M.L.,
RA   Naylor S.L., Kucherlapati R.S., Nelson D.L., Weinstock G.M., Sakaki Y.,
RA   Fujiyama A., Hattori M., Yada T., Toyoda A., Itoh T., Kawagoe C.,
RA   Watanabe H., Totoki Y., Taylor T., Weissenbach J., Heilig R., Saurin W.,
RA   Artiguenave F., Brottier P., Bruls T., Pelletier E., Robert C., Wincker P.,
RA   Smith D.R., Doucette-Stamm L., Rubenfield M., Weinstock K., Lee H.M.,
RA   Dubois J., Rosenthal A., Platzer M., Nyakatura G., Taudien S., Rump A.,
RA   Yang H., Yu J., Wang J., Huang G., Gu J., Hood L., Rowen L., Madan A.,
RA   Qin S., Davis R.W., Federspiel N.A., Abola A.P., Proctor M.J., Myers R.M.,
RA   Schmutz J., Dickson M., Grimwood J., Cox D.R., Olson M.V., Kaul R.,
RA   Raymond C., Shimizu N., Kawasaki K., Minoshima S., Evans G.A.,
RA   Athanasiou M., Schultz R., Roe B.A., Chen F., Pan H., Ramser J.,
RA   Lehrach H., Reinhardt R., McCombie W.R., de la Bastide M., Dedhia N.,
RA   Blocker H., Hornischer K., Nordsiek G., Agarwala R., Aravind L.,
RA   Bailey J.A., Bateman A., Batzoglou S., Birney E., Bork P., Brown D.G.,
RA   Burge C.B., Cerutti L., Chen H.C., Church D., Clamp M., Copley R.R.,
RA   Doerks T., Eddy S.R., Eichler E.E., Furey T.S., Galagan J., Gilbert J.G.,
RA   Harmon C., Hayashizaki Y., Haussler D., Hermjakob H., Hokamp K., Jang W.,
RA   Johnson L.S., Jones T.A., Kasif S., Kaspryzk A., Kennedy S., Kent W.J.,
RA   Kitts P., Koonin E.V., Korf I., Kulp D., Lancet D., Lowe T.M.,
RA   McLysaght A., Mikkelsen T., Moran J.V., Mulder N., Pollara V.J.,
RA   Ponting C.P., Schuler G., Schultz J., Slater G., Smit A.F., Stupka E.,
RA   Szustakowski J., Thierry-Mieg D., Thierry-Mieg J., Wagner L., Wallis J.,
RA   Wheeler R., Williams A., Wolf Y.I., Wolfe K.H., Yang S.P., Yeh R.F.,
RA   Collins F., Guyer M.S., Peterson J., Felsenfeld A., Wetterstrand K.A.,
RA   Patrinos A., Morgan M.J., de Jong P., Catanese J.J., Osoegawa K.,
RA   Shizuya H., Choi S., Chen Y.J.;
RT   "Initial sequencing and analysis of the human genome.";
RL   Nature 409:860-921(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000371869.6, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA   Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA   Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA   Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA   McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA   Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA   Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of discrete
RT   sequence classes.";
RL   Nature 423:825-837(2003).
RN   [3] {ECO:0000313|Ensembl:ENSP00000371869.6}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496913; DOI=10.1038/nature03001;
RG   International Human Genome Sequencing Consortium;
RT   "Finishing the euchromatic sequence of the human genome.";
RL   Nature 431:931-945(2004).
RN   [4] {ECO:0000313|Ensembl:ENSP00000371869.6}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2024) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AC006338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; E7ENA5; -.
DR   MassIVE; E7ENA5; -.
DR   PeptideAtlas; E7ENA5; -.
DR   Antibodypedia; 5164; 136 antibodies from 22 providers.
DR   Ensembl; ENST00000382432.9; ENSP00000371869.6; ENSG00000205916.12.
DR   UCSC; uc065cvy.1; human.
DR   HGNC; HGNC:15966; DAZ4.
DR   VEuPathDB; HostDB:ENSG00000205916; -.
DR   GeneTree; ENSGT00530000063480; -.
DR   OMA; HYNPIQY; -.
DR   ChiTaRS; DAZ4; human.
DR   Proteomes; UP000005640; Chromosome Y.
DR   Bgee; ENSG00000205916; Expressed in primordial germ cell in gonad and 11 other cell types or tissues.
DR   ExpressionAtlas; E7ENA5; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd12672; RRM_DAZL; 1.
DR   FunFam; 3.30.70.330:FF:000180; Deleted in azoospermia-like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR043628; DAZ_dom.
DR   InterPro; IPR037551; DAZ_RRM_vert.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR11176; BOULE-RELATED; 1.
DR   PANTHER; PTHR11176:SF8; DELETED IN AZOOSPERMIA PROTEIN 1-RELATED; 1.
DR   Pfam; PF18872; Daz; 15.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS51890; DAZ; 15.
DR   PROSITE; PS50102; RRM; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00176}; Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT   DOMAIN          40..115
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          167..190
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          191..214
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          215..238
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          239..262
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          263..286
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          287..310
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          311..334
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          335..358
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          359..382
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          383..406
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          407..430
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          431..454
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          455..478
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          479..502
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   DOMAIN          503..526
FT                   /note="DAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS51890"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   558 AA;  63142 MW;  9F9037A212053E62 CRC64;
     MSAANPETPN STISREASTQ SSSAAASQGW VLPEGKIVPN TVFVGGIDAR MDETEIGSCF
     GRYGSVKEVK IITNRTGVSK GYGFVSFVND VDVQKIVGSQ IHFHGKKLKL GPAIRKQKLC
     ARHVQPRPLV VNPPPPPQFQ NVWRNPNTET YLQPQITPNP VTQHVQAYSA YPHSPGQVIT
     GCQLLVYNYQ EYPTYPDSAF QVTTGYQLPV YNYQPFPAYP RSPFQVTAGY QLPVYNYQAF
     PAYPNSPFQV ATGYQFPVYN YQPFPAYPSS PFQVTAGYQL PVYNYQAFPA YPNSPFQVAT
     GYQFPVYNYQ AFPAYPNSPV QVTTGYQLPV YNYQAFPAYP NSPFQVATGY QFPVYNYQAF
     PAYPNSPVQV TTGYQLPVYN YQAFPAYPSS PFQVTTGYQL PVYNYQAFPA YPSSPFQVTT
     GYQLPVYNYQ AFPAYPSSPF QVTTGYQLPV YNYQAFPAYP SSPFQVTTGY QLPVYNYQAF
     PAYPSSPFQV TTGYQLPVYN YQAFPAYPNS AVQVTTGYQF HVYNYQMPPQ CPVGEQRRNL
     WTEAYKWWYL VCLIQRRD
//